Advanced heart failure and nocturnal hypoxaemia due to central sleep apnoea are associated with increased serum erythropoietin

Andrew D. Calvin, Virend K. Somers, David P. Steensma, Jose A. Rio Perez, Christelle Van Der Walt, Jennifer M. Fitz-Gibbon, Christopher G. Scott, Lyle J. Olson

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

AimsCentral sleep apnoea (CSA) and increased serum erythropoietin (EPO) concentration have each been associated with adverse prognosis in heart failure (HF) patients. The aim of this study was to examine the relationship between nocturnal hypoxaemia due to CSA and the serum EPO concentration in patients with HF.Methods and resultsHeart failure subjects (n = 33) and healthy controls (n = 18) underwent polysomnography (PSG) for diagnosis of CSA and identification and quantification of hypoxaemia. Blood collection for measurement of EPO was performed immediately post-PSG. For the analysis, HF subjects were dichotomized into subgroups defined by the presence or absence of CSA and by HF severity. Multivariate analyses were performed to evaluate the relationships of hypoxaemia and advanced HF to EPO concentration. Mean EPO concentration was 62 higher for HF subjects with CSA than for healthy controls (P = 0.004). The magnitude of nocturnal hypoxaemia was significantly and positively related to EPO concentration (r = 0.45, P = 0.02). Advanced HF was also significantly and positively related to EPO concentration (r = 0.43, P = 0.02). On multivariate analysis, the presence of combined nocturnal hypoxaemia and advanced HF yielded greater correlation to EPO concentration than either factor alone (r = 0.57, P = 0.04 and P = 0.05, respectively). Linear regression demonstrated that the combination of New York Heart Association Class and CSA was strongly associated with EPO concentration (P < 0.0001).ConclusionIn non-anaemic HF patients, advanced HF and hypoxaemia due to CSA may each be independently associated with increased serum EPO concentration.

Original languageEnglish (US)
Pages (from-to)354-359
Number of pages6
JournalEuropean Journal of Heart Failure
Volume12
Issue number4
DOIs
StatePublished - Apr 1 2010

Keywords

  • Erythropoietin
  • Heart failure
  • Hypoxaemia
  • Sleep apnoea

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Calvin, A. D., Somers, V. K., Steensma, D. P., Rio Perez, J. A., Van Der Walt, C., Fitz-Gibbon, J. M., Scott, C. G., & Olson, L. J. (2010). Advanced heart failure and nocturnal hypoxaemia due to central sleep apnoea are associated with increased serum erythropoietin. European Journal of Heart Failure, 12(4), 354-359. https://doi.org/10.1093/eurjhf/hfq005