Advanced EUS guided tissue acquisition methods for pancreatic cancer

Pujan Kandel, Michael B. Wallace

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Pancreas cancer is a lethal cancer as the majority patients are diagnosed at an advanced incurable stage. Despite improvements in diagnostic modalities and management strategies, including surgery and chemotherapies, the outcome of pancreas cancer remains poor. Endoscopic ultrasound (EUS) is an important imaging tool for pancreas cancer. For decades, resected pancreas cancer and other cancer specimens have been used to identify tissue biomarkers or genomics for precision therapy; however, only 20% of patients undergo surgery, and thus, this framework is not useful for unresectable pancreas cancer. With advancements in needle technologies, tumor specimens can be obtained at the time of tissue diagnosis. Tumor tissue can be used for development of personalized cancer treatment, such as performing whole exome sequencing and global genomic profiling of pancreas cancer, development of tissue biomarkers, and targeted mutational assays for precise chemotherapy treatment. In this review, we discuss the recent advances in tissue acquisition of pancreas cancer.

Original languageEnglish (US)
Article number54
JournalCancers
Volume10
Issue number2
DOIs
StatePublished - Feb 17 2018

Keywords

  • Endoscopic ultrasound
  • Pancreas cancer
  • Precision therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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