Advanced EUS guided tissue acquisition methods for pancreatic cancer

Pujan Kandel, Michael B. Wallace

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Pancreas cancer is a lethal cancer as the majority patients are diagnosed at an advanced incurable stage. Despite improvements in diagnostic modalities and management strategies, including surgery and chemotherapies, the outcome of pancreas cancer remains poor. Endoscopic ultrasound (EUS) is an important imaging tool for pancreas cancer. For decades, resected pancreas cancer and other cancer specimens have been used to identify tissue biomarkers or genomics for precision therapy; however, only 20% of patients undergo surgery, and thus, this framework is not useful for unresectable pancreas cancer. With advancements in needle technologies, tumor specimens can be obtained at the time of tissue diagnosis. Tumor tissue can be used for development of personalized cancer treatment, such as performing whole exome sequencing and global genomic profiling of pancreas cancer, development of tissue biomarkers, and targeted mutational assays for precise chemotherapy treatment. In this review, we discuss the recent advances in tissue acquisition of pancreas cancer.

Original languageEnglish (US)
Article number54
JournalCancers
Volume10
Issue number2
DOIs
StatePublished - Feb 17 2018

Fingerprint

Pancreatic Neoplasms
Neoplasms
Biomarkers
Exome
Drug Therapy
Genomics
Needles
Therapeutics
Technology

Keywords

  • Endoscopic ultrasound
  • Pancreas cancer
  • Precision therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Advanced EUS guided tissue acquisition methods for pancreatic cancer. / Kandel, Pujan; Wallace, Michael B.

In: Cancers, Vol. 10, No. 2, 54, 17.02.2018.

Research output: Contribution to journalReview article

Kandel, Pujan ; Wallace, Michael B. / Advanced EUS guided tissue acquisition methods for pancreatic cancer. In: Cancers. 2018 ; Vol. 10, No. 2.
@article{2c711c591b5e438fb44928d4f67fdadb,
title = "Advanced EUS guided tissue acquisition methods for pancreatic cancer",
abstract = "Pancreas cancer is a lethal cancer as the majority patients are diagnosed at an advanced incurable stage. Despite improvements in diagnostic modalities and management strategies, including surgery and chemotherapies, the outcome of pancreas cancer remains poor. Endoscopic ultrasound (EUS) is an important imaging tool for pancreas cancer. For decades, resected pancreas cancer and other cancer specimens have been used to identify tissue biomarkers or genomics for precision therapy; however, only 20{\%} of patients undergo surgery, and thus, this framework is not useful for unresectable pancreas cancer. With advancements in needle technologies, tumor specimens can be obtained at the time of tissue diagnosis. Tumor tissue can be used for development of personalized cancer treatment, such as performing whole exome sequencing and global genomic profiling of pancreas cancer, development of tissue biomarkers, and targeted mutational assays for precise chemotherapy treatment. In this review, we discuss the recent advances in tissue acquisition of pancreas cancer.",
keywords = "Endoscopic ultrasound, Pancreas cancer, Precision therapy",
author = "Pujan Kandel and Wallace, {Michael B.}",
year = "2018",
month = "2",
day = "17",
doi = "10.3390/cancers10020054",
language = "English (US)",
volume = "10",
journal = "Cancers",
issn = "2072-6694",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "2",

}

TY - JOUR

T1 - Advanced EUS guided tissue acquisition methods for pancreatic cancer

AU - Kandel, Pujan

AU - Wallace, Michael B.

PY - 2018/2/17

Y1 - 2018/2/17

N2 - Pancreas cancer is a lethal cancer as the majority patients are diagnosed at an advanced incurable stage. Despite improvements in diagnostic modalities and management strategies, including surgery and chemotherapies, the outcome of pancreas cancer remains poor. Endoscopic ultrasound (EUS) is an important imaging tool for pancreas cancer. For decades, resected pancreas cancer and other cancer specimens have been used to identify tissue biomarkers or genomics for precision therapy; however, only 20% of patients undergo surgery, and thus, this framework is not useful for unresectable pancreas cancer. With advancements in needle technologies, tumor specimens can be obtained at the time of tissue diagnosis. Tumor tissue can be used for development of personalized cancer treatment, such as performing whole exome sequencing and global genomic profiling of pancreas cancer, development of tissue biomarkers, and targeted mutational assays for precise chemotherapy treatment. In this review, we discuss the recent advances in tissue acquisition of pancreas cancer.

AB - Pancreas cancer is a lethal cancer as the majority patients are diagnosed at an advanced incurable stage. Despite improvements in diagnostic modalities and management strategies, including surgery and chemotherapies, the outcome of pancreas cancer remains poor. Endoscopic ultrasound (EUS) is an important imaging tool for pancreas cancer. For decades, resected pancreas cancer and other cancer specimens have been used to identify tissue biomarkers or genomics for precision therapy; however, only 20% of patients undergo surgery, and thus, this framework is not useful for unresectable pancreas cancer. With advancements in needle technologies, tumor specimens can be obtained at the time of tissue diagnosis. Tumor tissue can be used for development of personalized cancer treatment, such as performing whole exome sequencing and global genomic profiling of pancreas cancer, development of tissue biomarkers, and targeted mutational assays for precise chemotherapy treatment. In this review, we discuss the recent advances in tissue acquisition of pancreas cancer.

KW - Endoscopic ultrasound

KW - Pancreas cancer

KW - Precision therapy

UR - http://www.scopus.com/inward/record.url?scp=85042285845&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042285845&partnerID=8YFLogxK

U2 - 10.3390/cancers10020054

DO - 10.3390/cancers10020054

M3 - Review article

AN - SCOPUS:85042285845

VL - 10

JO - Cancers

JF - Cancers

SN - 2072-6694

IS - 2

M1 - 54

ER -