Adulthood lifetime physical activity and breast cancer

Beata Peplonska, Jolanta Lissowska, Terryl J. Hartman, Neonila Szeszenia-Dabrowska, Aaron Blair, Witold Zatonski, Mark E. Sherman, Montserrat Garcia-Closas, Louise A. Brinton

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Abstract

BACKGROUND: Epidemiologic studies have shown that breast cancer risk is reduced 30% to 40% in highly physically active compared with inactive women. However, the effects of moderate activities, timing of activities, and intervening effects of other risk factors remain less clear. METHODS: We analyzed data on physical activity patterns in 2176 incident breast cancer cases and 2326 controls in a population-based breast cancer case-control study in Poland conducted in 2000-2003. Using unconditional logistic regression analyses, we calculated odds ratios (ORs) and 95% confidence intervals (CIs) associated with physical activity levels (measured by average metabolic equivalents of energy expenditure hours per week), controlling for potential confounders. RESULTS: Total adult lifetime activity reduced risk of breast cancer, with individuals in the highest quartile having an OR of 0.80 (CI = 0.67-0.96) compared with the lowest quartile. Reduced risks were most consistent for the highest quartiles of moderate-to-vigorous activities: moderate/vigorous recreational activities (OR = 0.74; CI = 0.62-0.89), outdoor activities (0.81; 0.68-0.97), heavy physical work (0.60; 0.42-0.87), and combined high intensity (metabolic equivalent >6.0) activities (0.75; 0.63-0.90). These relations were not modified by body mass index, menopausal status, or family history of breast cancer. Reductions in risk with moderate/vigorous recreational activities were stronger for larger tumors and those with nodal involvement. Women who increased their recreational activity in their 50s had significantly reduced risk, with those in the highest tertile of change being at a 27% lower risk. CONCLUSIONS: Leisure-time moderate-to-vigorous activities reduce breast cancer risk irrespective of underlying host characteristics.

Original languageEnglish (US)
Pages (from-to)226-236
Number of pages11
JournalEpidemiology
Volume19
Issue number2
DOIs
StatePublished - Mar 2008

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Exercise
Breast Neoplasms
Metabolic Equivalent
Odds Ratio
Confidence Intervals
Leisure Activities
Poland
Risk Reduction Behavior
Energy Metabolism
Case-Control Studies
Epidemiologic Studies
Body Mass Index
Logistic Models
Regression Analysis
Population
Neoplasms

ASJC Scopus subject areas

  • Epidemiology

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Peplonska, B., Lissowska, J., Hartman, T. J., Szeszenia-Dabrowska, N., Blair, A., Zatonski, W., ... Brinton, L. A. (2008). Adulthood lifetime physical activity and breast cancer. Epidemiology, 19(2), 226-236. https://doi.org/10.1097/EDE.0b013e3181633bfb

Adulthood lifetime physical activity and breast cancer. / Peplonska, Beata; Lissowska, Jolanta; Hartman, Terryl J.; Szeszenia-Dabrowska, Neonila; Blair, Aaron; Zatonski, Witold; Sherman, Mark E.; Garcia-Closas, Montserrat; Brinton, Louise A.

In: Epidemiology, Vol. 19, No. 2, 03.2008, p. 226-236.

Research output: Contribution to journalArticle

Peplonska, B, Lissowska, J, Hartman, TJ, Szeszenia-Dabrowska, N, Blair, A, Zatonski, W, Sherman, ME, Garcia-Closas, M & Brinton, LA 2008, 'Adulthood lifetime physical activity and breast cancer', Epidemiology, vol. 19, no. 2, pp. 226-236. https://doi.org/10.1097/EDE.0b013e3181633bfb
Peplonska B, Lissowska J, Hartman TJ, Szeszenia-Dabrowska N, Blair A, Zatonski W et al. Adulthood lifetime physical activity and breast cancer. Epidemiology. 2008 Mar;19(2):226-236. https://doi.org/10.1097/EDE.0b013e3181633bfb
Peplonska, Beata ; Lissowska, Jolanta ; Hartman, Terryl J. ; Szeszenia-Dabrowska, Neonila ; Blair, Aaron ; Zatonski, Witold ; Sherman, Mark E. ; Garcia-Closas, Montserrat ; Brinton, Louise A. / Adulthood lifetime physical activity and breast cancer. In: Epidemiology. 2008 ; Vol. 19, No. 2. pp. 226-236.
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AU - Hartman, Terryl J.

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AU - Blair, Aaron

AU - Zatonski, Witold

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