Adult systemic anaplastic large-cell lymphoma: Recommendations for diagnosis and management

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10 Scopus citations

Abstract

Systemic anaplastic large-cell lymphomas (sALCLs) comprise a heterogeneous group of relatively rare T-cell non-Hodgkin lymphomas (NHLs) characterized by CD30 expression and other unifying pathologic features. Anaplastic lymphoma kinase (ALK) fusions are present in about 50% of cases. Pathological diagnosis can be challenging, particularly in ALK-negative cases. Though ALK-positive and ALK-negative sALCLs are similar morphologically and immunophenotypically, they are separate entities with different genetics, clinical behavior, and outcomes. Evidence-based data evaluating treatment regimens are limited as randomized controlled trials are lacking and most prospective studies are too small to draw definitive conclusions. However, recent advances in molecular biology are bringing forth much-needed knowledge in this field, and are likely to guide further targeted therapeutic development.

Original languageEnglish (US)
Pages (from-to)137-150
Number of pages14
JournalExpert Review of Hematology
Volume9
Issue number2
DOIs
StatePublished - Feb 1 2016

Keywords

  • ALK translocation
  • Anaplastic large-cell lymphoma
  • DUSP22 rearrangements
  • NPM-ALK fusion
  • T-cell non-Hodgkin lymphoma
  • brentuximab vedotin
  • crizotinib

ASJC Scopus subject areas

  • Hematology

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