Adult Patients With Bronchiectasis: A First Look at the US Bronchiectasis Research Registry

For the, Bronchiectasis Research Registry Consortium

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Objectives We sought to describe the characteristics of adult patients with bronchiectasis enrolled in the US Bronchiectasis Research Registry (BRR). Methods The BRR is a database of patients with non-cystic-fibrosis bronchiectasis (NCFB) enrolled at 13 sites in the United States. Baseline demographic, spirometric, imaging, microbiological, and therapeutic data were entered into a central Internet-based database. Patients were subsequently analyzed by the presence of NTM. Results We enrolled 1,826 patients between 2008 and 2014. Patients were predominantly women (79%), white (89%), and never smokers (60%), with a mean age of 64 ± 14 years. Sixty-three percent of the patients had a history of NTM disease or NTM isolated at baseline evaluation for entry into the BRR. Patients with NTM were older, predominantly women, and had bronchiectasis diagnosed at a later age than those without NTM. Gastroesophageal reflux disease (GERD) was more common in those with NTM, whereas asthma, primary immunodeficiency, and primary ciliary dyskinesia were more common in those without NTM. Fifty-one percent of patients had spirometric evidence of airflow obstruction. Patients with NTM were more likely to have diffusely dilated airways and tree-in-bud abnormalities. Pseudomonas and Staphylococcus aureus isolates were cultured less commonly in patients with NTM. Bronchial hygiene measures were used more often in those with NTM, whereas antibiotics used for exacerbations, rotating oral antibiotics, steroid use, and inhaled bronchodilators were more commonly used in those without NTM. Conclusions Adult patients with bronchiectasis enrolled in the US BRR are described, with differences noted in demographic, radiographic, microbiological, and treatment variables based on stratification of the presence of NTM.

Original languageEnglish (US)
Pages (from-to)982-992
Number of pages11
JournalChest
Volume151
Issue number5
DOIs
StatePublished - May 1 2017

Fingerprint

Bronchiectasis
Registries
Research
Demography
Kartagener Syndrome
Databases
Anti-Bacterial Agents
Bronchodilator Agents
Gastroesophageal Reflux
Pseudomonas
Hygiene
Internet
Staphylococcus aureus
Fibrosis
Asthma
Steroids

Keywords

  • airways
  • bronchiectasis
  • nontuberculous mycobacteria
  • Pseudomonas
  • registry

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Adult Patients With Bronchiectasis : A First Look at the US Bronchiectasis Research Registry. / For the; Bronchiectasis Research Registry Consortium.

In: Chest, Vol. 151, No. 5, 01.05.2017, p. 982-992.

Research output: Contribution to journalArticle

For the & Bronchiectasis Research Registry Consortium 2017, 'Adult Patients With Bronchiectasis: A First Look at the US Bronchiectasis Research Registry', Chest, vol. 151, no. 5, pp. 982-992. https://doi.org/10.1016/j.chest.2016.10.055
For the ; Bronchiectasis Research Registry Consortium. / Adult Patients With Bronchiectasis : A First Look at the US Bronchiectasis Research Registry. In: Chest. 2017 ; Vol. 151, No. 5. pp. 982-992.
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abstract = "Objectives We sought to describe the characteristics of adult patients with bronchiectasis enrolled in the US Bronchiectasis Research Registry (BRR). Methods The BRR is a database of patients with non-cystic-fibrosis bronchiectasis (NCFB) enrolled at 13 sites in the United States. Baseline demographic, spirometric, imaging, microbiological, and therapeutic data were entered into a central Internet-based database. Patients were subsequently analyzed by the presence of NTM. Results We enrolled 1,826 patients between 2008 and 2014. Patients were predominantly women (79{\%}), white (89{\%}), and never smokers (60{\%}), with a mean age of 64 ± 14 years. Sixty-three percent of the patients had a history of NTM disease or NTM isolated at baseline evaluation for entry into the BRR. Patients with NTM were older, predominantly women, and had bronchiectasis diagnosed at a later age than those without NTM. Gastroesophageal reflux disease (GERD) was more common in those with NTM, whereas asthma, primary immunodeficiency, and primary ciliary dyskinesia were more common in those without NTM. Fifty-one percent of patients had spirometric evidence of airflow obstruction. Patients with NTM were more likely to have diffusely dilated airways and tree-in-bud abnormalities. Pseudomonas and Staphylococcus aureus isolates were cultured less commonly in patients with NTM. Bronchial hygiene measures were used more often in those with NTM, whereas antibiotics used for exacerbations, rotating oral antibiotics, steroid use, and inhaled bronchodilators were more commonly used in those without NTM. Conclusions Adult patients with bronchiectasis enrolled in the US BRR are described, with differences noted in demographic, radiographic, microbiological, and treatment variables based on stratification of the presence of NTM.",
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AU - Aksamit, Timothy

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AU - Barker, Alan

AU - Olivier, Kenneth N.

AU - Winthrop, Kevin L.

AU - Daniels, M. Leigh Anne

AU - Johnson, Margaret

AU - Eden, Edward

AU - Griffith, David

AU - Knowles, Michael

AU - Metersky, Mark

AU - Salathe, Matthias

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KW - bronchiectasis

KW - nontuberculous mycobacteria

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