Adult-onset, short-term dietary restriction reduces cell senescence in mice

Chunfang Wang, Mandy Maddick, Satomi Miwa, Diana Jurk, Rafal Czapiewski, Gabriele Saretzki, Sabine A.S. Langie, Roger W.L. Godschalk, Kerry Cameron, Thomas von Zglinicki

Research output: Contribution to journalArticle

91 Scopus citations

Abstract

Dietary restriction (DR) extends the lifespan of a wide variety of species and reduces the incidence of major agerelated diseases. Cell senescence has been proposed as one causal mechanism for tissue and organism ageing. We show for the first time that adult-onset, short-term DR reduced frequencies of senescent cells in the small intestinal epithelium and liver of mice, which are tissues known to accumulate increased numbers of senescent cells with advancing age. This reduction was associated with improved telomere maintenance without increased telomerase activity. We also found a decrease in cumulative oxidative stress markers in the same compartments despite absence of significant changes in steady-state oxidative stress markers at the whole tissue level. The data suggest the possibility that reduction of cell senescence may be a primary consequence of DR which in turn may explain known effects of DR such as improved mitochondrial function and reduced production of reactive oxygen species.

Original languageEnglish (US)
Pages (from-to)555-566
Number of pages12
JournalAging
Volume2
Issue number9
DOIs
StatePublished - Sep 2010

Keywords

  • Ageing
  • Caloric restriction
  • Dietary restriction
  • Mice
  • Senescence
  • Telomeres

ASJC Scopus subject areas

  • Aging
  • Cell Biology

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    Wang, C., Maddick, M., Miwa, S., Jurk, D., Czapiewski, R., Saretzki, G., Langie, S. A. S., Godschalk, R. W. L., Cameron, K., & von Zglinicki, T. (2010). Adult-onset, short-term dietary restriction reduces cell senescence in mice. Aging, 2(9), 555-566. https://doi.org/10.18632/aging.100196