Adult height in patients with congenital adrenal hyperplasia: A systematic review and metaanalysis

Kalpana Muthusamy, Mohamed B. Elamin, Galina Smushkin, Mohammad Hassan Murad, Julianna F. Lampropulos, Khalid B. Elamin, Nisrin O. Abu Elnour, Juan F. Gallegos-Orozco, Mitra M. Fatourechi, Neera Agrwal, Melanie A. Lane, Felipe N. Albuquerque, Patricia J. Erwin, Victor M. Montori

Research output: Contribution to journalReview article

79 Scopus citations

Abstract

Context: Treatment for patients with congenital adrenal hyperplasia (CAH) may affect the final height of these patients. Objective: Our objective was to determine the distribution of achieved height in patients with classic CAH diagnosed at infancy or early childhood and treated with glucocorticoids. Data Sources: We searched MEDLINE, EMBASE, Cochrane Library, ISI Web of Science, and Scopus through September 2008; the reference sections of included studies; and expert files. Study Selection: Eligible studies included patients diagnosed with CAH before age 5 and followed to final height. Data Extraction: Reviewers working in duplicate independently extracted data on study characteristics and outcomes and determined each study's risk of bias. Data Synthesis: The SD score (SDS) for final height and corrected height (defined as final height SDS - midparental height SDS) were estimated from each study and pooled using random-effects metaanalysis. The I2 statistic was used to assess inconsistency in results across studies. Results: We found 35 eligible studies, most of which were retrospective single-cohort studies. The final height SDS achieved by CAH patients was -1.38 (-1.56 to -1.20; I2 - 90.2%), and the corrected height SDS was -1.03 (-1.20 to -0.86; I2 = 63.1%). This was not significantly associated with age at diagnosis, gender, type and dose of steroid, and age of onset of puberty. Mineralocorticoid users had a better height outcome in comparison with the nonusers (P = 0.02). Conclusion: Evidence derived from observational studies suggests that the final height of CAH patients treated with glucocorticoids is lower than the populationnormand is lower than expected given parental height.

Original languageEnglish (US)
Pages (from-to)4161-4172
Number of pages12
JournalJournal of Clinical Endocrinology and Metabolism
Volume95
Issue number9
DOIs
StatePublished - Sep 2010

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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    Muthusamy, K., Elamin, M. B., Smushkin, G., Murad, M. H., Lampropulos, J. F., Elamin, K. B., Abu Elnour, N. O., Gallegos-Orozco, J. F., Fatourechi, M. M., Agrwal, N., Lane, M. A., Albuquerque, F. N., Erwin, P. J., & Montori, V. M. (2010). Adult height in patients with congenital adrenal hyperplasia: A systematic review and metaanalysis. Journal of Clinical Endocrinology and Metabolism, 95(9), 4161-4172. https://doi.org/10.1210/jc.2009-2616