Adult energy requirements predicted from doubly labeled water

Andrew Plucker, Diana M. Thomas, Nick Broskey, Corby K. Martin, Dale Schoeller, Robin Shook, Steven B. Heymsfield, James A. Levine, Leanne A. Redman

Research output: Contribution to journalArticle

Abstract

Background: Estimating energy requirements forms an integral part of developing diet and activity interventions. Current estimates often rely on a product of physical activity level (PAL) and a resting metabolic rate (RMR) prediction. PAL estimates, however, typically depend on subjective self-reported activity or a clinician’s best guess. Energy-requirement models that do not depend on an input of PAL may provide an attractive alternative. Methods: Total daily energy expenditure (TEE) measured by doubly labeled water (DLW) and a metabolic chamber from 119 subjects obtained from a database of pre-intervention measurements measured at Pennington Biomedical Research Center were used to develop a metabolic ward and free-living models that predict energy requirements. Graded models, including different combinations of input variables consisting of age, height, weight, waist circumference, body composition, and the resting metabolic rate were developed. The newly developed models were validated and compared to three independent databases. Results: Sixty-four different linear and nonlinear regression models were developed. The adjusted R2 for models predicting free-living energy requirements ranged from 0.65 with covariates of age, height, and weight to 0.74 in models that included body composition and RMR. Independent validation R2 between actual and predicted TEE varied greatly across studies and between genders with higher coefficients of determination, lower bias, slopes closer to 1, and intercepts closer to zero, associated with inclusion of body composition and RMR covariates. The models were programmed into a user-friendly web-based app available at: http://www.pbrc.edu/research-and-faculty/calculators/energy-requirements/ (Video Demo for Reviewers at: https://www.youtube.com/watch?v=5UKjJeQdODQ) Conclusions: Energy-requirement equations that do not require knowledge of activity levels and include all available input variables can provide more accurate baseline estimates. The models are clinically accessible through the web-based application.

Original languageEnglish (US)
JournalInternational Journal of Obesity
DOIs
StateAccepted/In press - Jan 1 2018

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Basal Metabolism
Body Composition
Water
Exercise
Energy Metabolism
Databases
Weights and Measures
Nonlinear Dynamics
Inclusion Bodies
Waist Circumference
Biomedical Research
Linear Models
Diet
Research

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Plucker, A., Thomas, D. M., Broskey, N., Martin, C. K., Schoeller, D., Shook, R., ... Redman, L. A. (Accepted/In press). Adult energy requirements predicted from doubly labeled water. International Journal of Obesity. https://doi.org/10.1038/s41366-018-0168-0

Adult energy requirements predicted from doubly labeled water. / Plucker, Andrew; Thomas, Diana M.; Broskey, Nick; Martin, Corby K.; Schoeller, Dale; Shook, Robin; Heymsfield, Steven B.; Levine, James A.; Redman, Leanne A.

In: International Journal of Obesity, 01.01.2018.

Research output: Contribution to journalArticle

Plucker, A, Thomas, DM, Broskey, N, Martin, CK, Schoeller, D, Shook, R, Heymsfield, SB, Levine, JA & Redman, LA 2018, 'Adult energy requirements predicted from doubly labeled water', International Journal of Obesity. https://doi.org/10.1038/s41366-018-0168-0
Plucker, Andrew ; Thomas, Diana M. ; Broskey, Nick ; Martin, Corby K. ; Schoeller, Dale ; Shook, Robin ; Heymsfield, Steven B. ; Levine, James A. ; Redman, Leanne A. / Adult energy requirements predicted from doubly labeled water. In: International Journal of Obesity. 2018.
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