Adrenomedullin: Potential in physiology and pathophysiology

Michihisa Jougasaki, John C Jr. Burnett

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

Adrenomedullin (ADM), a 52-amino acid ringed-structure peptide with C- terminal amidation, was originally isolated from human pheochromocytoma. ADM mediates vasodilatory and natriuretic properties through the second messenger cyclic adenosine 3',5'-monophosphate (cAMP), nitric oxide and the renal prostaglandin system. ADM immunoreactivity and its gene are widely distributed in cardiovascular, pulmonary, renal, gastrointestinal, cerebral and endocrine tissues. ADM is also synthesized and secreted from vascular endothelial and smooth muscle cells. When injected intravenously, ADM increases flow rates predominantly in organs in which the ADM gene is highly expressed, suggesting that ADM acts as a local autocrine and/or paracrine vasoactive hormone. In addition, ADM is a circulating hormone and its plasma concentration is increased in various cardiorenal diseases such as hypertension, chronic renal failure and congestive heart failure. Current evidence suggests that ADM plays an important role in fluid and electrolyte homeostasis and cardiorenal regulation, however further investigations are required to address the importance of ADM under various physiological and pathophysiological conditions.

Original languageEnglish (US)
Pages (from-to)855-872
Number of pages18
JournalLife Sciences
Volume66
Issue number10
DOIs
StatePublished - Jan 28 2000

Fingerprint

Adrenomedullin
Physiology
Genes
Hormones
Kidney
Second Messenger Systems
Pheochromocytoma
Vascular Smooth Muscle
Cyclic AMP
Electrolytes
Chronic Kidney Failure
Prostaglandins
Smooth Muscle Myocytes
Muscle
Nitric Oxide
Homeostasis
Heart Failure
Cells
Flow rate
Tissue

Keywords

  • Adrenomedullin
  • Hormone
  • Peptide

ASJC Scopus subject areas

  • Pharmacology

Cite this

Adrenomedullin : Potential in physiology and pathophysiology. / Jougasaki, Michihisa; Burnett, John C Jr.

In: Life Sciences, Vol. 66, No. 10, 28.01.2000, p. 855-872.

Research output: Contribution to journalArticle

Jougasaki, Michihisa ; Burnett, John C Jr. / Adrenomedullin : Potential in physiology and pathophysiology. In: Life Sciences. 2000 ; Vol. 66, No. 10. pp. 855-872.
@article{b629b9d8887a44e4beae7f8f8d43366f,
title = "Adrenomedullin: Potential in physiology and pathophysiology",
abstract = "Adrenomedullin (ADM), a 52-amino acid ringed-structure peptide with C- terminal amidation, was originally isolated from human pheochromocytoma. ADM mediates vasodilatory and natriuretic properties through the second messenger cyclic adenosine 3',5'-monophosphate (cAMP), nitric oxide and the renal prostaglandin system. ADM immunoreactivity and its gene are widely distributed in cardiovascular, pulmonary, renal, gastrointestinal, cerebral and endocrine tissues. ADM is also synthesized and secreted from vascular endothelial and smooth muscle cells. When injected intravenously, ADM increases flow rates predominantly in organs in which the ADM gene is highly expressed, suggesting that ADM acts as a local autocrine and/or paracrine vasoactive hormone. In addition, ADM is a circulating hormone and its plasma concentration is increased in various cardiorenal diseases such as hypertension, chronic renal failure and congestive heart failure. Current evidence suggests that ADM plays an important role in fluid and electrolyte homeostasis and cardiorenal regulation, however further investigations are required to address the importance of ADM under various physiological and pathophysiological conditions.",
keywords = "Adrenomedullin, Hormone, Peptide",
author = "Michihisa Jougasaki and Burnett, {John C Jr.}",
year = "2000",
month = "1",
day = "28",
doi = "10.1016/S0024-3205(99)00358-6",
language = "English (US)",
volume = "66",
pages = "855--872",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "10",

}

TY - JOUR

T1 - Adrenomedullin

T2 - Potential in physiology and pathophysiology

AU - Jougasaki, Michihisa

AU - Burnett, John C Jr.

PY - 2000/1/28

Y1 - 2000/1/28

N2 - Adrenomedullin (ADM), a 52-amino acid ringed-structure peptide with C- terminal amidation, was originally isolated from human pheochromocytoma. ADM mediates vasodilatory and natriuretic properties through the second messenger cyclic adenosine 3',5'-monophosphate (cAMP), nitric oxide and the renal prostaglandin system. ADM immunoreactivity and its gene are widely distributed in cardiovascular, pulmonary, renal, gastrointestinal, cerebral and endocrine tissues. ADM is also synthesized and secreted from vascular endothelial and smooth muscle cells. When injected intravenously, ADM increases flow rates predominantly in organs in which the ADM gene is highly expressed, suggesting that ADM acts as a local autocrine and/or paracrine vasoactive hormone. In addition, ADM is a circulating hormone and its plasma concentration is increased in various cardiorenal diseases such as hypertension, chronic renal failure and congestive heart failure. Current evidence suggests that ADM plays an important role in fluid and electrolyte homeostasis and cardiorenal regulation, however further investigations are required to address the importance of ADM under various physiological and pathophysiological conditions.

AB - Adrenomedullin (ADM), a 52-amino acid ringed-structure peptide with C- terminal amidation, was originally isolated from human pheochromocytoma. ADM mediates vasodilatory and natriuretic properties through the second messenger cyclic adenosine 3',5'-monophosphate (cAMP), nitric oxide and the renal prostaglandin system. ADM immunoreactivity and its gene are widely distributed in cardiovascular, pulmonary, renal, gastrointestinal, cerebral and endocrine tissues. ADM is also synthesized and secreted from vascular endothelial and smooth muscle cells. When injected intravenously, ADM increases flow rates predominantly in organs in which the ADM gene is highly expressed, suggesting that ADM acts as a local autocrine and/or paracrine vasoactive hormone. In addition, ADM is a circulating hormone and its plasma concentration is increased in various cardiorenal diseases such as hypertension, chronic renal failure and congestive heart failure. Current evidence suggests that ADM plays an important role in fluid and electrolyte homeostasis and cardiorenal regulation, however further investigations are required to address the importance of ADM under various physiological and pathophysiological conditions.

KW - Adrenomedullin

KW - Hormone

KW - Peptide

UR - http://www.scopus.com/inward/record.url?scp=0034723350&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034723350&partnerID=8YFLogxK

U2 - 10.1016/S0024-3205(99)00358-6

DO - 10.1016/S0024-3205(99)00358-6

M3 - Article

C2 - 10714887

AN - SCOPUS:0034723350

VL - 66

SP - 855

EP - 872

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 10

ER -