Adrenocortical carcinoma with inferior vena cava tumor thrombus

Danuel V. Laan, Cornelius A. Thiels, Amy Glasgow, Kevin B. Wise, Geoffrey B. Thompson, Melanie L. Richards, David R. Farley, Mark Truty, Travis J. McKenzie

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background The safety, efficacy, and prognostic implications of resection of adrenocortical carcinoma with inferior vena cava tumor thrombus are poorly described. Methods A retrospective review was performed during a 30-year period on patients who underwent resection of locally advanced, nonmetastatic adrenocortical carcinoma. We compared patients with and without inferior vena cava tumor thrombus, examining perioperative characteristics, completeness of resection, mortality, and survival. Results We identified 65 patients who underwent resection of locally advanced (T4N0 and T4N1) adrenocortical carcinoma (28 patients with inferior vena cava tumor thrombus, 37 noninferior vena cava tumor thrombus). Rate of complete resection, adjuvant chemotherapy, and short-term postoperative morbidity was similar between groups. Overall survival was similar at 12-months. At 24 months overall survival was less in the inferior vena cava tumor thrombus group (59% vs 30%, P = .04). Differential survival through 60-month follow-up favored the noninferior vena cava tumor thrombus group (36% vs 0%, P = .001). Subgroup analysis including only patients with complete resection demonstrates similar survival at 24-months but at 36-months survival favored the noninferior vena cava tumor thrombus patients (65% vs 29%, P = .047) and this continued through 60 months (40% vs 0%, P = .049). Conclusion Attempt at complete resection of adrenocortical carcinoma with inferior vena cava tumor thrombus seems justified particularly as short-term safety and survival are similar to patients without inferior vena cava tumor thrombus. However, survival beyond 36-months is limited in patients with inferior vena cava tumor thrombus. Patients being evaluated for resection in the setting of inferior vena cava tumor thrombus should be selected carefully.

Original languageEnglish (US)
Pages (from-to)240-248
Number of pages9
JournalSurgery (United States)
Volume161
Issue number1
DOIs
StatePublished - Jan 1 2017

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Adrenocortical Carcinoma
Inferior Vena Cava
Thrombosis
Survival
Neoplasms
Venae Cavae
Safety
Adjuvant Chemotherapy

ASJC Scopus subject areas

  • Surgery

Cite this

Laan, D. V., Thiels, C. A., Glasgow, A., Wise, K. B., Thompson, G. B., Richards, M. L., ... McKenzie, T. J. (2017). Adrenocortical carcinoma with inferior vena cava tumor thrombus. Surgery (United States), 161(1), 240-248. https://doi.org/10.1016/j.surg.2016.07.040

Adrenocortical carcinoma with inferior vena cava tumor thrombus. / Laan, Danuel V.; Thiels, Cornelius A.; Glasgow, Amy; Wise, Kevin B.; Thompson, Geoffrey B.; Richards, Melanie L.; Farley, David R.; Truty, Mark; McKenzie, Travis J.

In: Surgery (United States), Vol. 161, No. 1, 01.01.2017, p. 240-248.

Research output: Contribution to journalArticle

Laan, DV, Thiels, CA, Glasgow, A, Wise, KB, Thompson, GB, Richards, ML, Farley, DR, Truty, M & McKenzie, TJ 2017, 'Adrenocortical carcinoma with inferior vena cava tumor thrombus', Surgery (United States), vol. 161, no. 1, pp. 240-248. https://doi.org/10.1016/j.surg.2016.07.040
Laan DV, Thiels CA, Glasgow A, Wise KB, Thompson GB, Richards ML et al. Adrenocortical carcinoma with inferior vena cava tumor thrombus. Surgery (United States). 2017 Jan 1;161(1):240-248. https://doi.org/10.1016/j.surg.2016.07.040
Laan, Danuel V. ; Thiels, Cornelius A. ; Glasgow, Amy ; Wise, Kevin B. ; Thompson, Geoffrey B. ; Richards, Melanie L. ; Farley, David R. ; Truty, Mark ; McKenzie, Travis J. / Adrenocortical carcinoma with inferior vena cava tumor thrombus. In: Surgery (United States). 2017 ; Vol. 161, No. 1. pp. 240-248.
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abstract = "Background The safety, efficacy, and prognostic implications of resection of adrenocortical carcinoma with inferior vena cava tumor thrombus are poorly described. Methods A retrospective review was performed during a 30-year period on patients who underwent resection of locally advanced, nonmetastatic adrenocortical carcinoma. We compared patients with and without inferior vena cava tumor thrombus, examining perioperative characteristics, completeness of resection, mortality, and survival. Results We identified 65 patients who underwent resection of locally advanced (T4N0 and T4N1) adrenocortical carcinoma (28 patients with inferior vena cava tumor thrombus, 37 noninferior vena cava tumor thrombus). Rate of complete resection, adjuvant chemotherapy, and short-term postoperative morbidity was similar between groups. Overall survival was similar at 12-months. At 24 months overall survival was less in the inferior vena cava tumor thrombus group (59{\%} vs 30{\%}, P = .04). Differential survival through 60-month follow-up favored the noninferior vena cava tumor thrombus group (36{\%} vs 0{\%}, P = .001). Subgroup analysis including only patients with complete resection demonstrates similar survival at 24-months but at 36-months survival favored the noninferior vena cava tumor thrombus patients (65{\%} vs 29{\%}, P = .047) and this continued through 60 months (40{\%} vs 0{\%}, P = .049). Conclusion Attempt at complete resection of adrenocortical carcinoma with inferior vena cava tumor thrombus seems justified particularly as short-term safety and survival are similar to patients without inferior vena cava tumor thrombus. However, survival beyond 36-months is limited in patients with inferior vena cava tumor thrombus. Patients being evaluated for resection in the setting of inferior vena cava tumor thrombus should be selected carefully.",
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T1 - Adrenocortical carcinoma with inferior vena cava tumor thrombus

AU - Laan, Danuel V.

AU - Thiels, Cornelius A.

AU - Glasgow, Amy

AU - Wise, Kevin B.

AU - Thompson, Geoffrey B.

AU - Richards, Melanie L.

AU - Farley, David R.

AU - Truty, Mark

AU - McKenzie, Travis J.

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N2 - Background The safety, efficacy, and prognostic implications of resection of adrenocortical carcinoma with inferior vena cava tumor thrombus are poorly described. Methods A retrospective review was performed during a 30-year period on patients who underwent resection of locally advanced, nonmetastatic adrenocortical carcinoma. We compared patients with and without inferior vena cava tumor thrombus, examining perioperative characteristics, completeness of resection, mortality, and survival. Results We identified 65 patients who underwent resection of locally advanced (T4N0 and T4N1) adrenocortical carcinoma (28 patients with inferior vena cava tumor thrombus, 37 noninferior vena cava tumor thrombus). Rate of complete resection, adjuvant chemotherapy, and short-term postoperative morbidity was similar between groups. Overall survival was similar at 12-months. At 24 months overall survival was less in the inferior vena cava tumor thrombus group (59% vs 30%, P = .04). Differential survival through 60-month follow-up favored the noninferior vena cava tumor thrombus group (36% vs 0%, P = .001). Subgroup analysis including only patients with complete resection demonstrates similar survival at 24-months but at 36-months survival favored the noninferior vena cava tumor thrombus patients (65% vs 29%, P = .047) and this continued through 60 months (40% vs 0%, P = .049). Conclusion Attempt at complete resection of adrenocortical carcinoma with inferior vena cava tumor thrombus seems justified particularly as short-term safety and survival are similar to patients without inferior vena cava tumor thrombus. However, survival beyond 36-months is limited in patients with inferior vena cava tumor thrombus. Patients being evaluated for resection in the setting of inferior vena cava tumor thrombus should be selected carefully.

AB - Background The safety, efficacy, and prognostic implications of resection of adrenocortical carcinoma with inferior vena cava tumor thrombus are poorly described. Methods A retrospective review was performed during a 30-year period on patients who underwent resection of locally advanced, nonmetastatic adrenocortical carcinoma. We compared patients with and without inferior vena cava tumor thrombus, examining perioperative characteristics, completeness of resection, mortality, and survival. Results We identified 65 patients who underwent resection of locally advanced (T4N0 and T4N1) adrenocortical carcinoma (28 patients with inferior vena cava tumor thrombus, 37 noninferior vena cava tumor thrombus). Rate of complete resection, adjuvant chemotherapy, and short-term postoperative morbidity was similar between groups. Overall survival was similar at 12-months. At 24 months overall survival was less in the inferior vena cava tumor thrombus group (59% vs 30%, P = .04). Differential survival through 60-month follow-up favored the noninferior vena cava tumor thrombus group (36% vs 0%, P = .001). Subgroup analysis including only patients with complete resection demonstrates similar survival at 24-months but at 36-months survival favored the noninferior vena cava tumor thrombus patients (65% vs 29%, P = .047) and this continued through 60 months (40% vs 0%, P = .049). Conclusion Attempt at complete resection of adrenocortical carcinoma with inferior vena cava tumor thrombus seems justified particularly as short-term safety and survival are similar to patients without inferior vena cava tumor thrombus. However, survival beyond 36-months is limited in patients with inferior vena cava tumor thrombus. Patients being evaluated for resection in the setting of inferior vena cava tumor thrombus should be selected carefully.

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