Adrenergic control of nerve blood flow

Douglas W. Zochodne, Phillip Anson Low

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

The factors that regulate blood flow within peripheral nerve (NBF) are largely unexplored. The presence of norepinephrine (NE)-containing terminals on vasa nervorum suggests that adrenergic regulation may be important. In this study we investigated the adrenergic responsiveness of NBF to agonist and antagonist agents using three separate techniques: (i) laser doppler flow-metry (LDV) using an epineurial probe, (ii) hydrogen clearance (HC) using an endoneurial microelectrode, and (iii) direct video recording (VA) of epineurial microvessels. Selective intraarterial NE delivery induced a phentolamine-reversible fall in NBF. Phentolamine alone increased NBF and lowered microvascular resistance (MR) as measured by HC. Epineurial microvessels had segmental vasoconstriction to bathing solutions of NE as observed by VA. Our findings suggest that NBF responds to adrenergic manipulation, possibly due to a heterogeneous distribution of α receptors on epineurial vessels that supply the endoneurium.

Original languageEnglish (US)
Pages (from-to)300-307
Number of pages8
JournalExperimental Neurology
Volume109
Issue number3
DOIs
StatePublished - 1990

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Adrenergic Agents
Norepinephrine
Phentolamine
Microvessels
Peripheral Nerves
Hydrogen
Vasa Nervorum
Video Recording
Microelectrodes
Vasoconstriction
Lasers

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology

Cite this

Adrenergic control of nerve blood flow. / Zochodne, Douglas W.; Low, Phillip Anson.

In: Experimental Neurology, Vol. 109, No. 3, 1990, p. 300-307.

Research output: Contribution to journalArticle

Zochodne, Douglas W. ; Low, Phillip Anson. / Adrenergic control of nerve blood flow. In: Experimental Neurology. 1990 ; Vol. 109, No. 3. pp. 300-307.
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