TY - JOUR
T1 - Adrenergic control of nerve blood flow
AU - Zochodne, Douglas W.
AU - Low, Phillip A.
N1 - Funding Information:
This research was supported in part by grants from NINCDS (R01 NS2 2352, NS14302), MDS, and Mogg and Mayo Funds. Dr. Low is the recipient of a Jacob Javits Neuroscience Award. Dr. Zochodne received research fellowship support from the Medical Research Council of Canada. Lisa Fregeau and James Schmelzer provided invaluable assistance.
PY - 1990/9
Y1 - 1990/9
N2 - The factors that regulate blood flow within peripheral nerve (NBF) are largely unexplored. The presence of norepinephrine (NE)-containing terminals on vasa nervorum suggests that adrenergic regulation may be important. In this study we investigated the adrenergic responsiveness of NBF to agonist and antagonist agents using three separate techniques: (i) laser doppler flow-metry (LDV) using an epineurial probe, (ii) hydrogen clearance (HC) using an endoneurial microelectrode, and (iii) direct video recording (VA) of epineurial microvessels. Selective intraarterial NE delivery induced a phentolamine-reversible fall in NBF. Phentolamine alone increased NBF and lowered microvascular resistance (MR) as measured by HC. Epineurial microvessels had segmental vasoconstriction to bathing solutions of NE as observed by VA. Our findings suggest that NBF responds to adrenergic manipulation, possibly due to a heterogeneous distribution of α receptors on epineurial vessels that supply the endoneurium.
AB - The factors that regulate blood flow within peripheral nerve (NBF) are largely unexplored. The presence of norepinephrine (NE)-containing terminals on vasa nervorum suggests that adrenergic regulation may be important. In this study we investigated the adrenergic responsiveness of NBF to agonist and antagonist agents using three separate techniques: (i) laser doppler flow-metry (LDV) using an epineurial probe, (ii) hydrogen clearance (HC) using an endoneurial microelectrode, and (iii) direct video recording (VA) of epineurial microvessels. Selective intraarterial NE delivery induced a phentolamine-reversible fall in NBF. Phentolamine alone increased NBF and lowered microvascular resistance (MR) as measured by HC. Epineurial microvessels had segmental vasoconstriction to bathing solutions of NE as observed by VA. Our findings suggest that NBF responds to adrenergic manipulation, possibly due to a heterogeneous distribution of α receptors on epineurial vessels that supply the endoneurium.
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U2 - 10.1016/S0014-4886(05)80021-4
DO - 10.1016/S0014-4886(05)80021-4
M3 - Article
C2 - 2285433
AN - SCOPUS:0025169010
SN - 0014-4886
VL - 109
SP - 300
EP - 307
JO - Experimental Neurology
JF - Experimental Neurology
IS - 3
ER -