Adrenal, thyroid and gonadal axes are affected at high altitude

M. Von Wolff, C. T. Nakas, M. Tobler, T. M. Merz, M. P. Hilty, Johannes D Veldhuis, A. R. Huber, J. Pichler Hefti

Research output: Contribution to journalArticle

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Abstract

Humans cannot live at very high altitude for reasons, which are not completely understood. Since these reasons are not restricted to cardiorespiratory changes alone, changes in the endocrine system might also be involved. Therefore, hormonal changes during prolonged hypobaric hypoxia were comprehensively assessed to determine effects of altitude and hypoxia on stress, thyroid and gonadal hypothalamus–pituitary hormone axes. Twenty-one male and 19 female participants were examined repetitively during a high-altitude expedition. Cortisol, prolactin, thyroid-stimulating hormone (TSH), fT4 and fT3 and in males follicle-stimulating hormone (FSH), luteinizing hormone (LH) and total testosterone were analysed as well as parameters of hypoxemia, such as SaO2 and paO2 at 550 m (baseline) (n = 40), during ascent at 4844 m (n = 38), 6022 m (n = 31) and 7050 m (n = 13), at 4844 m (n = 29) after acclimatization and after the expedition (n = 38). Correlation analysis of hormone concentrations with oxygen parameters and with altitude revealed statistical association in most cases only with altitude. Adrenal, thyroid and gonadal axes were affected by increasing altitude. Adrenal axis and prolactin were first supressed at 4844 m and then activated with increasing altitude; thyroid and gonadal axes were directly activated or suppressed respectively with increasing altitude. Acclimatisation at 4844 m led to normalization of adrenal and gonadal but not of thyroid axes. In conclusion, acclimatization partly leads to a normalization of the adrenal, thyroid and gonadal axes at around 5000 m. However, at higher altitude, endocrine dysregulation is pronounced and might contribute to the physical degradation found at high altitude.

Original languageEnglish (US)
Pages (from-to)1081-1089
Number of pages9
JournalEndocrine Connections
Volume7
Issue number10
DOIs
StatePublished - Jan 1 2018

Fingerprint

Thyroid Gland
Acclimatization
Expeditions
Prolactin
Altitude Sickness
Gonadal Hormones
Endocrine System
Follicle Stimulating Hormone
Thyrotropin
Luteinizing Hormone
Hydrocortisone
Testosterone
Hormones
Oxygen

Keywords

  • Altitude
  • Cortisol
  • Follicle-stimulation hormone
  • FT3
  • FT4
  • Hypobaric hypoxia
  • Luteinizing hormone
  • Prolactin
  • Testosterone
  • TSH

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Wolff, M. V., Nakas, C. T., Tobler, M., Merz, T. M., Hilty, M. P., Veldhuis, J. D., ... Hefti, J. P. (2018). Adrenal, thyroid and gonadal axes are affected at high altitude. Endocrine Connections, 7(10), 1081-1089. https://doi.org/10.1530/EC-18-0242

Adrenal, thyroid and gonadal axes are affected at high altitude. / Wolff, M. Von; Nakas, C. T.; Tobler, M.; Merz, T. M.; Hilty, M. P.; Veldhuis, Johannes D; Huber, A. R.; Hefti, J. Pichler.

In: Endocrine Connections, Vol. 7, No. 10, 01.01.2018, p. 1081-1089.

Research output: Contribution to journalArticle

Wolff, MV, Nakas, CT, Tobler, M, Merz, TM, Hilty, MP, Veldhuis, JD, Huber, AR & Hefti, JP 2018, 'Adrenal, thyroid and gonadal axes are affected at high altitude', Endocrine Connections, vol. 7, no. 10, pp. 1081-1089. https://doi.org/10.1530/EC-18-0242
Wolff MV, Nakas CT, Tobler M, Merz TM, Hilty MP, Veldhuis JD et al. Adrenal, thyroid and gonadal axes are affected at high altitude. Endocrine Connections. 2018 Jan 1;7(10):1081-1089. https://doi.org/10.1530/EC-18-0242
Wolff, M. Von ; Nakas, C. T. ; Tobler, M. ; Merz, T. M. ; Hilty, M. P. ; Veldhuis, Johannes D ; Huber, A. R. ; Hefti, J. Pichler. / Adrenal, thyroid and gonadal axes are affected at high altitude. In: Endocrine Connections. 2018 ; Vol. 7, No. 10. pp. 1081-1089.
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