Adrenal incidentaloma

Geoffrey B. Thompson, William Francis Young

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Adrenal incidentalomas are incidentally discovered adrenal masses greater than 1 cm in diameter that appear to be clinically nonfunctioning. They are detected during imaging procedures of the abdomen and chest (CT, MRI, and ultrasonography) for an unrelated condition or symptom complex. With the widespread escalation in the use of these imaging modalities and marked improvements in image resolution, the probability of finding an incidentaloma on cross-section imaging is rapidly approaching the 6% prevalence of previously reported autopsy studies. All incidentalomas greater than 1 cm should be evaluated for hormonal activity, including a 1-mg overnight dexamethasone suppression test, total 24-hour urinary metanephrines and fractionated catecholamines, and, in the hypertensive patient, a serum potassium level and plasma aldosterone concentration to plasma renin activity ratio. All hormonally active tumors should be removed. Hormonally inactive tumors are resected based on size, imaging phenotype, and interval growth. Percutaneous biopsies are generally unwarranted and are potentially dangerous. Laparoscopic adrenalectomy has become the surgical procedure of choice for most benign functioning and nonfunctioning tumors of the adrenal gland. Subclinical metabolic abnormalities associated with adrenal incidentalomas remain an area of intense clinical research.

Original languageEnglish (US)
Pages (from-to)84-90
Number of pages7
JournalCurrent Opinion in Oncology
Volume15
Issue number1
DOIs
StatePublished - Jan 2003

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Metanephrine
Neoplasms
Adrenalectomy
Adrenal Glands
Aldosterone
Renin
Abdomen
Dexamethasone
Catecholamines
Autopsy
Ultrasonography
Potassium
Thorax
Phenotype
Biopsy
Growth
Serum
Research
Adrenal incidentaloma

ASJC Scopus subject areas

  • Cancer Research

Cite this

Adrenal incidentaloma. / Thompson, Geoffrey B.; Young, William Francis.

In: Current Opinion in Oncology, Vol. 15, No. 1, 01.2003, p. 84-90.

Research output: Contribution to journalArticle

Thompson, Geoffrey B. ; Young, William Francis. / Adrenal incidentaloma. In: Current Opinion in Oncology. 2003 ; Vol. 15, No. 1. pp. 84-90.
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