Adrenal adenomas: Relationship between histologic lipid and CT and MR findings

Melvyn Korobkin, Thomas J. Giordano, Frederick J. Brodeur, Isaac R. Francis, Evan S. Siegelman, Leslie E. Quint, N. Reed Dunnick, Jay Heiken, Helena H. Wang

Research output: Contribution to journalArticle

222 Citations (Scopus)

Abstract

PURPOSE: To assess the relationship between the quantity of lipid in resected adrenal adenomas and the unenhanced computed tomographic (CT) attenuation number and the relative change in signal intensity on chemical shift magnetic resonance (MR) images. MATERIALS AND METHODS: The percentage of lipid-rich cortical cells in histologic sections from 20 resected adrenal adenomas was assessed. The results were correlated with the corresponding unenhanced CT attenuation number or the relative change in signal intensity on chemical shift MR images, or both. RESULTS: There was an inverse linear relationship between the percentage of lipid-rich cortical cells in the adrenal adenomas and the unenhanced CT attenuation number (R2 = .68, P = .0005). There was a similar inverse linear relationship to the relative change in MR signal intensity on chemical shift images by using both quantitative (R2 = .83, P = .004) and qualitative (R2 = .70, P = .019) assessment. CONCLUSION: The presence and amount of histologic lipid in many adrenal adenomas accounts for their low attenuation on unenhanced CT scans and their loss in relative signal intensity on chemical shift MR images.

Original languageEnglish (US)
Pages (from-to)743-747
Number of pages5
JournalRadiology
Volume200
Issue number3
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

Fingerprint

Adenoma
Magnetic Resonance Spectroscopy
Lipids

Keywords

  • Adrenal gland, CT
  • Adrenal gland, MR
  • Adrenal gland, neoplasms
  • Fat
  • Magnetic resonance (MR), chemical shift

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Korobkin, M., Giordano, T. J., Brodeur, F. J., Francis, I. R., Siegelman, E. S., Quint, L. E., ... Wang, H. H. (1996). Adrenal adenomas: Relationship between histologic lipid and CT and MR findings. Radiology, 200(3), 743-747. https://doi.org/10.1148/radiology.200.3.8756925

Adrenal adenomas : Relationship between histologic lipid and CT and MR findings. / Korobkin, Melvyn; Giordano, Thomas J.; Brodeur, Frederick J.; Francis, Isaac R.; Siegelman, Evan S.; Quint, Leslie E.; Dunnick, N. Reed; Heiken, Jay; Wang, Helena H.

In: Radiology, Vol. 200, No. 3, 01.01.1996, p. 743-747.

Research output: Contribution to journalArticle

Korobkin, M, Giordano, TJ, Brodeur, FJ, Francis, IR, Siegelman, ES, Quint, LE, Dunnick, NR, Heiken, J & Wang, HH 1996, 'Adrenal adenomas: Relationship between histologic lipid and CT and MR findings', Radiology, vol. 200, no. 3, pp. 743-747. https://doi.org/10.1148/radiology.200.3.8756925
Korobkin M, Giordano TJ, Brodeur FJ, Francis IR, Siegelman ES, Quint LE et al. Adrenal adenomas: Relationship between histologic lipid and CT and MR findings. Radiology. 1996 Jan 1;200(3):743-747. https://doi.org/10.1148/radiology.200.3.8756925
Korobkin, Melvyn ; Giordano, Thomas J. ; Brodeur, Frederick J. ; Francis, Isaac R. ; Siegelman, Evan S. ; Quint, Leslie E. ; Dunnick, N. Reed ; Heiken, Jay ; Wang, Helena H. / Adrenal adenomas : Relationship between histologic lipid and CT and MR findings. In: Radiology. 1996 ; Vol. 200, No. 3. pp. 743-747.
@article{c5a121b3d4de4ccca70c0027aedea142,
title = "Adrenal adenomas: Relationship between histologic lipid and CT and MR findings",
abstract = "PURPOSE: To assess the relationship between the quantity of lipid in resected adrenal adenomas and the unenhanced computed tomographic (CT) attenuation number and the relative change in signal intensity on chemical shift magnetic resonance (MR) images. MATERIALS AND METHODS: The percentage of lipid-rich cortical cells in histologic sections from 20 resected adrenal adenomas was assessed. The results were correlated with the corresponding unenhanced CT attenuation number or the relative change in signal intensity on chemical shift MR images, or both. RESULTS: There was an inverse linear relationship between the percentage of lipid-rich cortical cells in the adrenal adenomas and the unenhanced CT attenuation number (R2 = .68, P = .0005). There was a similar inverse linear relationship to the relative change in MR signal intensity on chemical shift images by using both quantitative (R2 = .83, P = .004) and qualitative (R2 = .70, P = .019) assessment. CONCLUSION: The presence and amount of histologic lipid in many adrenal adenomas accounts for their low attenuation on unenhanced CT scans and their loss in relative signal intensity on chemical shift MR images.",
keywords = "Adrenal gland, CT, Adrenal gland, MR, Adrenal gland, neoplasms, Fat, Magnetic resonance (MR), chemical shift",
author = "Melvyn Korobkin and Giordano, {Thomas J.} and Brodeur, {Frederick J.} and Francis, {Isaac R.} and Siegelman, {Evan S.} and Quint, {Leslie E.} and Dunnick, {N. Reed} and Jay Heiken and Wang, {Helena H.}",
year = "1996",
month = "1",
day = "1",
doi = "10.1148/radiology.200.3.8756925",
language = "English (US)",
volume = "200",
pages = "743--747",
journal = "Radiology",
issn = "0033-8419",
publisher = "Radiological Society of North America Inc.",
number = "3",

}

TY - JOUR

T1 - Adrenal adenomas

T2 - Relationship between histologic lipid and CT and MR findings

AU - Korobkin, Melvyn

AU - Giordano, Thomas J.

AU - Brodeur, Frederick J.

AU - Francis, Isaac R.

AU - Siegelman, Evan S.

AU - Quint, Leslie E.

AU - Dunnick, N. Reed

AU - Heiken, Jay

AU - Wang, Helena H.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - PURPOSE: To assess the relationship between the quantity of lipid in resected adrenal adenomas and the unenhanced computed tomographic (CT) attenuation number and the relative change in signal intensity on chemical shift magnetic resonance (MR) images. MATERIALS AND METHODS: The percentage of lipid-rich cortical cells in histologic sections from 20 resected adrenal adenomas was assessed. The results were correlated with the corresponding unenhanced CT attenuation number or the relative change in signal intensity on chemical shift MR images, or both. RESULTS: There was an inverse linear relationship between the percentage of lipid-rich cortical cells in the adrenal adenomas and the unenhanced CT attenuation number (R2 = .68, P = .0005). There was a similar inverse linear relationship to the relative change in MR signal intensity on chemical shift images by using both quantitative (R2 = .83, P = .004) and qualitative (R2 = .70, P = .019) assessment. CONCLUSION: The presence and amount of histologic lipid in many adrenal adenomas accounts for their low attenuation on unenhanced CT scans and their loss in relative signal intensity on chemical shift MR images.

AB - PURPOSE: To assess the relationship between the quantity of lipid in resected adrenal adenomas and the unenhanced computed tomographic (CT) attenuation number and the relative change in signal intensity on chemical shift magnetic resonance (MR) images. MATERIALS AND METHODS: The percentage of lipid-rich cortical cells in histologic sections from 20 resected adrenal adenomas was assessed. The results were correlated with the corresponding unenhanced CT attenuation number or the relative change in signal intensity on chemical shift MR images, or both. RESULTS: There was an inverse linear relationship between the percentage of lipid-rich cortical cells in the adrenal adenomas and the unenhanced CT attenuation number (R2 = .68, P = .0005). There was a similar inverse linear relationship to the relative change in MR signal intensity on chemical shift images by using both quantitative (R2 = .83, P = .004) and qualitative (R2 = .70, P = .019) assessment. CONCLUSION: The presence and amount of histologic lipid in many adrenal adenomas accounts for their low attenuation on unenhanced CT scans and their loss in relative signal intensity on chemical shift MR images.

KW - Adrenal gland, CT

KW - Adrenal gland, MR

KW - Adrenal gland, neoplasms

KW - Fat

KW - Magnetic resonance (MR), chemical shift

UR - http://www.scopus.com/inward/record.url?scp=0029787115&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029787115&partnerID=8YFLogxK

U2 - 10.1148/radiology.200.3.8756925

DO - 10.1148/radiology.200.3.8756925

M3 - Article

C2 - 8756925

AN - SCOPUS:0029787115

VL - 200

SP - 743

EP - 747

JO - Radiology

JF - Radiology

SN - 0033-8419

IS - 3

ER -