Adoptive T cell therapy of solid cancers

Keith L. Knutson, Wolfgang Wagner, Mary L. Disis

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

The development of immune-based approaches for the treatment of cancer has been actively investigated for many years. One strategy that has emerged as a potentially effective strategy for the treatment of aggressive established malignancies is adoptive T cell therapy. The power of this approach has been repeatedly observed in preclinical animal models. However, moving from homogeneous animal models to the heterogeneous human clinical setting has been very difficult. It is only in recent times that we have been able to pinpoint the problems of the clinical translation of adoptive T cell therapy. Some of the major problems are sources of tumor-specific T cells, ex vivo expansion, persistence, and anti-tumor activity. This review overviews the nature of these problems and some of the emerging solutions.

Original languageEnglish (US)
Pages (from-to)96-103
Number of pages8
JournalCancer Immunology, Immunotherapy
Volume55
Issue number1
DOIs
StatePublished - Jan 1 2006

Keywords

  • Adoptive T cell therapy
  • Antibody therapy
  • Cytokine therapy
  • Tumor immunology
  • Vaccines

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology
  • Cancer Research

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