Administration of Ginseng radix decreases nitric oxide synthase expression in the hippocampus of streptozotocin-induced diabetic rats

Hyun Kyung Chang, Mi Hyeon Jang, Baek Vin Lim, Taeck Hyun Lee, Min Chul Shin, Mal Soon Shin, Hong Kim, Young Pyo Kim, Ee Hwa Kim, Chang Ju Kim

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Nitric oxide (NO) is synthesized from L-arginine by nitric oxide synthase (NOS). Alternation of NOS expression is implicated in the pathogenesis of numerous secondary complications of diabetes. Aqueous extract of Ginseng radix has traditionally been used for the various disorders including diabetes. In this study, the effect of Ginseng radix on the NOS expression in the hippocampus of streptozotocin (STZ)-induced diabetic rats was investigated via nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry. Enhanced NOS expression was detected in the hippocampus of diabetic rats and administration of Ginseng radix suppressed NOS expression. Ginseng radix may aid the treatment of central nervous system complications in diabetes.

Original languageEnglish (US)
Pages (from-to)497-507
Number of pages11
JournalAmerican Journal of Chinese Medicine
Volume32
Issue number4
DOIs
StatePublished - Oct 12 2004

Keywords

  • Diabetes
  • Ginseng radix
  • Hippocampus
  • Nicotinamide adenine dinucleotide phosphate-diaphorase
  • Nitric oxide synthase

ASJC Scopus subject areas

  • Complementary and alternative medicine

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