Adjuvant therapy of triple negative breast cancer

Edith A. Perez, Alvaro Moreno-Aspitia, E. Aubrey Thompson, Cathy A. Andorfer

Research output: Contribution to journalReview article

39 Scopus citations

Abstract

Patients with the triple negative subtype of breast cancer have an overall poor outcome, with earlier relapses, distinct patterns of metastases, and lack of specific targets for treatment selection. Classification of these tumors has begun to be modified by inclusion of immunohistochemistry for various markers, and gene profiling. Further characterization of this subtype of breast cancer may aid in the identification of new targeted therapies. Anthracyclines and taxanes remain the standard of care in the adjuvant setting. However, novel anti-angiogenesis, anti-tubulin, and DNA repair agents are already under evaluation in (neo) adjuvant trials. Molecular characterization is being included in trials to identify optimal adjuvant strategies. The aim of this manuscript is to review data concerning the molecular characterization of triple negative breast cancers as well as the clinical outcomes of treating patients with existing adjuvant treatments, and to highlight newer adjuvant research strategies in development.

Original languageEnglish (US)
Pages (from-to)285-291
Number of pages7
JournalBreast Cancer Research and Treatment
Volume120
Issue number2
DOIs
StatePublished - Apr 1 2010

Keywords

  • Adjuvant therapy
  • Basal-like breast cancer
  • Breast cancer
  • Triple negative

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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