Adjuvant docetaxel plus doxorubicin and cyclophosphamide increases survival compared with fluorouracil plus doxorubicin and cyclophosphamide in women with operable node-positive breast cancer

Vivek Roy, Edith A. Perez

Research output: Contribution to journalComment/debate


In summary, on the basis of available data, TAC can be considered as an acceptable option for patients with resected node-positive breast cancer and a step in the ongoing evolution of adjuvant chemotherapy regimens. The significantly increased toxicity of the regimen cannot be overlooked and the oncologists should carefully evaluate the efficacy/toxicity ratio of the regimen on an individualised basis; including the addition of prophylactic growth factor support. Whether TAC will prove superior to the other contemporary regimens, such as dose-dense AC → T, must await the results of ongoing clinical trials. Patients should be encouraged to enroll in these and other clinical trials whenever possible.

Original languageEnglish (US)
Pages (from-to)55-58
Number of pages4
JournalCancer Treatment Reviews
Issue number1
StatePublished - Feb 2006


ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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