Adjuvant activity for alkylamines of immune responses to ovalbumin, myelin basic protein and a tumor

W. T. Shier, J. T. Trotter, C. L. Reading, Vanda A Lennon

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Emulsions of ovalbumin in alkylamines, particularly octadecylamine, were compared with an emulsion of ovalbumin in complete Freund's adjuvant for ability to induce humoral and cell mediated immune responses in rats. Under defined conditions alkylamine emulsions induced significantly higher IgG immune responses to ovalbumin, but cell mediated immunity was not significantly different from that induced with complete Freund's adjuvant. Emulsions of syngeneic myelin basic protein in octadecylamine failed to induce either humoral or cell mediated immunity to basic protein and neither clinical nor histologic signs of experimental allergic encephalomyelitis ensued. An intranodular injection of octadecylamine into a solid tumor caused significantly enhanced growth of the tumor despite marked necrosis of tumor tissue at the site of injection.

Original languageEnglish (US)
Pages (from-to)688-695
Number of pages8
JournalInternational Archives of Allergy and Applied Immunology
Volume47
Issue number5
StatePublished - 1974
Externally publishedYes

Fingerprint

Myelin Basic Protein
Ovalbumin
Emulsions
Freund's Adjuvant
Cellular Immunity
Neoplasms
Injections
Autoimmune Experimental Encephalomyelitis
Necrosis
Immunoglobulin G
Growth
stearylamine
Proteins

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Adjuvant activity for alkylamines of immune responses to ovalbumin, myelin basic protein and a tumor. / Shier, W. T.; Trotter, J. T.; Reading, C. L.; Lennon, Vanda A.

In: International Archives of Allergy and Applied Immunology, Vol. 47, No. 5, 1974, p. 688-695.

Research output: Contribution to journalArticle

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