Adjunct corticosteroid treatment in patients with pneumonia: A precision medicine approach

Srdjan Gavrilovic, Ana Andrijevic, Aida Mujakovic, Yewande Odeyemi, Belma Paralija, Ognjen Gajic

Research output: Contribution to journalReview article

Abstract

Pneumonia is the leading infectious cause of death worldwide. While inflammation is critically important in host response to microbial invasion, exaggerated inflammation can damage the lungs, contributing to respiratory failure and mortality. Corticosteroids are effective in reducing inflammation and can also cause immune suppression. Presently, clinicians are unable to reliably distinguish between exaggerated and appropriate immune response and thus cannot rapidly identify patients most likely to benefit from adjunctive corticosteroids. In this review, we propose a biomarker-guided, precision medicine approach to corticosteroid treatment, aimed to give these medications at appropriate dose and time and only to patients who have exaggerated inflammation.

Original languageEnglish (US)
Pages (from-to)315-320
Number of pages6
JournalBosnian journal of basic medical sciences
Volume19
Issue number4
DOIs
StatePublished - Nov 8 2019

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Precision Medicine
Pneumonia
Adrenal Cortex Hormones
Inflammation
Therapeutics
Respiratory Insufficiency
Cause of Death
Biomarkers
Lung
Mortality

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Adjunct corticosteroid treatment in patients with pneumonia : A precision medicine approach. / Gavrilovic, Srdjan; Andrijevic, Ana; Mujakovic, Aida; Odeyemi, Yewande; Paralija, Belma; Gajic, Ognjen.

In: Bosnian journal of basic medical sciences, Vol. 19, No. 4, 08.11.2019, p. 315-320.

Research output: Contribution to journalReview article

Gavrilovic, Srdjan ; Andrijevic, Ana ; Mujakovic, Aida ; Odeyemi, Yewande ; Paralija, Belma ; Gajic, Ognjen. / Adjunct corticosteroid treatment in patients with pneumonia : A precision medicine approach. In: Bosnian journal of basic medical sciences. 2019 ; Vol. 19, No. 4. pp. 315-320.
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