Adiposity, body composition and ventricular-arterial stiffness in the elderly

The Atherosclerosis Risk in Communities Study

Miguel M. Fernandes-Silva, Amil M. Shah, Brian Claggett, Susan Cheng, Hirofumi Tanaka, Odilson M. Silvestre, Wilson Nadruz, Barry A Borlaug, Scott D. Solomon

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Aim: Weight gain appears to accelerate age-related ventricular-arterial stiffening, which has been implicated in the development of heart failure (HF), but it is unclear whether body fat accumulation underpins this association. We evaluated the relationship of adiposity, using measures of body composition, with ventricular-arterial stiffness among the elderly in the community. Methods and results: Adiposity was accessed through body mass index (BMI), waist circumference, and body fat percentage. We studied the association of these measures with carotid-femoral pulse wave velocity (cfPWV), arterial elastance index (EaI), left ventricular (LV) end-systolic elastance index (EesI) and LV end-diastolic elastance index (EedI) in 5520 community-based, elderly Atherosclerosis Risk in Communities (ARIC) Study participants, who underwent echocardiography between 2011 and 2013. BMI and waist circumference were directly associated with EaI, EedI and EesI even after adjusting for age, sex, race, hypertension, diabetes mellitus, heart rate, prevalent coronary heart disease and HF. After further adjustment for BMI, body fat percentage demonstrated significant independent linear relationships with EaI [standardized beta coefficient (β)=0.17, P<0.001], EesI (β=0.08, P=0.003) and EedI (β=0.20, P<0.001), and significant non-linear relationships with cfPWV (P=0.033). Conclusion: In this biracial community-based cohort, increased adiposity was associated with increased ventricular-arterial stiffness among the elderly and suggests a potential mechanism by which obesity might contribute to the development of HF.

Original languageEnglish (US)
JournalEuropean Journal of Heart Failure
DOIs
StateAccepted/In press - Jan 1 2018
Externally publishedYes

Fingerprint

Vascular Stiffness
Adiposity
Body Composition
Atherosclerosis
Adipose Tissue
Pulse Wave Analysis
Body Mass Index
Heart Failure
Waist Circumference
Thigh
Weight Gain
Coronary Disease
Echocardiography
Diabetes Mellitus
Obesity
Heart Rate
Hypertension

Keywords

  • Adiposity
  • Aging
  • Arterial stiffness
  • Obesity
  • Ventricular stiffness

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Fernandes-Silva, M. M., Shah, A. M., Claggett, B., Cheng, S., Tanaka, H., Silvestre, O. M., ... Solomon, S. D. (Accepted/In press). Adiposity, body composition and ventricular-arterial stiffness in the elderly: The Atherosclerosis Risk in Communities Study. European Journal of Heart Failure. https://doi.org/10.1002/ejhf.1188

Adiposity, body composition and ventricular-arterial stiffness in the elderly : The Atherosclerosis Risk in Communities Study. / Fernandes-Silva, Miguel M.; Shah, Amil M.; Claggett, Brian; Cheng, Susan; Tanaka, Hirofumi; Silvestre, Odilson M.; Nadruz, Wilson; Borlaug, Barry A; Solomon, Scott D.

In: European Journal of Heart Failure, 01.01.2018.

Research output: Contribution to journalArticle

Fernandes-Silva, Miguel M. ; Shah, Amil M. ; Claggett, Brian ; Cheng, Susan ; Tanaka, Hirofumi ; Silvestre, Odilson M. ; Nadruz, Wilson ; Borlaug, Barry A ; Solomon, Scott D. / Adiposity, body composition and ventricular-arterial stiffness in the elderly : The Atherosclerosis Risk in Communities Study. In: European Journal of Heart Failure. 2018.
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abstract = "Aim: Weight gain appears to accelerate age-related ventricular-arterial stiffening, which has been implicated in the development of heart failure (HF), but it is unclear whether body fat accumulation underpins this association. We evaluated the relationship of adiposity, using measures of body composition, with ventricular-arterial stiffness among the elderly in the community. Methods and results: Adiposity was accessed through body mass index (BMI), waist circumference, and body fat percentage. We studied the association of these measures with carotid-femoral pulse wave velocity (cfPWV), arterial elastance index (EaI), left ventricular (LV) end-systolic elastance index (EesI) and LV end-diastolic elastance index (EedI) in 5520 community-based, elderly Atherosclerosis Risk in Communities (ARIC) Study participants, who underwent echocardiography between 2011 and 2013. BMI and waist circumference were directly associated with EaI, EedI and EesI even after adjusting for age, sex, race, hypertension, diabetes mellitus, heart rate, prevalent coronary heart disease and HF. After further adjustment for BMI, body fat percentage demonstrated significant independent linear relationships with EaI [standardized beta coefficient (β)=0.17, P<0.001], EesI (β=0.08, P=0.003) and EedI (β=0.20, P<0.001), and significant non-linear relationships with cfPWV (P=0.033). Conclusion: In this biracial community-based cohort, increased adiposity was associated with increased ventricular-arterial stiffness among the elderly and suggests a potential mechanism by which obesity might contribute to the development of HF.",
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AU - Shah, Amil M.

AU - Claggett, Brian

AU - Cheng, Susan

AU - Tanaka, Hirofumi

AU - Silvestre, Odilson M.

AU - Nadruz, Wilson

AU - Borlaug, Barry A

AU - Solomon, Scott D.

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N2 - Aim: Weight gain appears to accelerate age-related ventricular-arterial stiffening, which has been implicated in the development of heart failure (HF), but it is unclear whether body fat accumulation underpins this association. We evaluated the relationship of adiposity, using measures of body composition, with ventricular-arterial stiffness among the elderly in the community. Methods and results: Adiposity was accessed through body mass index (BMI), waist circumference, and body fat percentage. We studied the association of these measures with carotid-femoral pulse wave velocity (cfPWV), arterial elastance index (EaI), left ventricular (LV) end-systolic elastance index (EesI) and LV end-diastolic elastance index (EedI) in 5520 community-based, elderly Atherosclerosis Risk in Communities (ARIC) Study participants, who underwent echocardiography between 2011 and 2013. BMI and waist circumference were directly associated with EaI, EedI and EesI even after adjusting for age, sex, race, hypertension, diabetes mellitus, heart rate, prevalent coronary heart disease and HF. After further adjustment for BMI, body fat percentage demonstrated significant independent linear relationships with EaI [standardized beta coefficient (β)=0.17, P<0.001], EesI (β=0.08, P=0.003) and EedI (β=0.20, P<0.001), and significant non-linear relationships with cfPWV (P=0.033). Conclusion: In this biracial community-based cohort, increased adiposity was associated with increased ventricular-arterial stiffness among the elderly and suggests a potential mechanism by which obesity might contribute to the development of HF.

AB - Aim: Weight gain appears to accelerate age-related ventricular-arterial stiffening, which has been implicated in the development of heart failure (HF), but it is unclear whether body fat accumulation underpins this association. We evaluated the relationship of adiposity, using measures of body composition, with ventricular-arterial stiffness among the elderly in the community. Methods and results: Adiposity was accessed through body mass index (BMI), waist circumference, and body fat percentage. We studied the association of these measures with carotid-femoral pulse wave velocity (cfPWV), arterial elastance index (EaI), left ventricular (LV) end-systolic elastance index (EesI) and LV end-diastolic elastance index (EedI) in 5520 community-based, elderly Atherosclerosis Risk in Communities (ARIC) Study participants, who underwent echocardiography between 2011 and 2013. BMI and waist circumference were directly associated with EaI, EedI and EesI even after adjusting for age, sex, race, hypertension, diabetes mellitus, heart rate, prevalent coronary heart disease and HF. After further adjustment for BMI, body fat percentage demonstrated significant independent linear relationships with EaI [standardized beta coefficient (β)=0.17, P<0.001], EesI (β=0.08, P=0.003) and EedI (β=0.20, P<0.001), and significant non-linear relationships with cfPWV (P=0.033). Conclusion: In this biracial community-based cohort, increased adiposity was associated with increased ventricular-arterial stiffness among the elderly and suggests a potential mechanism by which obesity might contribute to the development of HF.

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