Adipose tissue metabolism in benign symmetric lipomatosis

Søren Nielsen, James A. Levine, Ricky Clay, Michael Dennis Jensen

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Type 2 benign symmetric lipomatosis (BSL) is characterized by abnormal growth of adipose tissue in the upper back, deltoid region, upper arms, hips, and upper thigh region. Studies of lipomatous tissue in vitro have suggested that defective lipolysis may account for excess fat accumulation; however, in vivo adipose tissue metabolism has not been evaluated. We measured systemic adipose tissue lipolysis and regional adipose tissue fatty acid uptake in a patient with type 2 BSL scheduled for elective brachioplasty. We found increased, rather than decreased, rates of systemic free fatty acid release coupled with normal fatty acid oxidation. The uptake of fatty acids was 19% greater in deltoid region lipomatous tissue than in abdominal sc fat, whereas in control studies the relative uptake of fatty acids in deltoid fat averaged 29% less than that in abdominal fat. Adipocyte size was smaller than expected in lipomatous tissue. These results suggest that type 2 BSL is a hyperplastic adipose tissue abnormality that does not impair systemic lipolysis. The pathophysiology appears similar to what has been termed hyperplastic obesity. A better understanding of this condition could lead to insights into the mechanisms of hyperplastic obesity.

Original languageEnglish (US)
Pages (from-to)2717-2720
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume86
Issue number6
DOIs
StatePublished - 2001

Fingerprint

Lipomatosis
Metabolism
Adipose Tissue
Tissue
Lipolysis
Fatty Acids
Abdominal Fat
Fats
Obesity
Thigh
Nonesterified Fatty Acids
Adipocytes
Hip
Arm
Growth
Oxidation

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Adipose tissue metabolism in benign symmetric lipomatosis. / Nielsen, Søren; Levine, James A.; Clay, Ricky; Jensen, Michael Dennis.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 86, No. 6, 2001, p. 2717-2720.

Research output: Contribution to journalArticle

Nielsen, Søren ; Levine, James A. ; Clay, Ricky ; Jensen, Michael Dennis. / Adipose tissue metabolism in benign symmetric lipomatosis. In: Journal of Clinical Endocrinology and Metabolism. 2001 ; Vol. 86, No. 6. pp. 2717-2720.
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