Adenoviruses (Ads) are arguably one of the most potent vectors for in vivo gene delivery. They are also thought to be one of the most immunogenic vectors driving potent cellular and humoral immune responses. While this immunogenicity can be a handicap in using Ads for gene therapy, this feature can be a potent strength when Ads are instead used as gene-based vaccine. This chapter discussed this application area for Ad vectors.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)