TY - JOUR
T1 - Adenosine-associated delivery systems
AU - Kazemzadeh-Narbat, Mehdi
AU - Annabi, Nasim
AU - Tamayol, Ali
AU - Oklu, Rahmi
AU - Ghanem, Amyl
AU - Khademhosseini, Ali
N1 - Funding Information:
The authors acknowledge funding from the National Science Foundation (EFRI-1240443), IMMODGEL (602694), and the National Institutes of Health (EB012597, AR057837, DE021468, HL099073, AI105024, AR063745).
Publisher Copyright:
© 2015 Taylor & Francis.
PY - 2015/9/14
Y1 - 2015/9/14
N2 - Adenosine is a naturally occurring purine nucleoside in every cell. Many critical treatments such as modulating irregular heartbeat (arrhythmias), regulation of central nervous system (CNS) activity and inhibiting seizural episodes can be carried out using adenosine. Despite the significant potential therapeutic impact of adenosine and its derivatives, the severe side effects caused by their systemic administration have significantly limited their clinical use. In addition, due to adenosines extremely short half-life in human blood (<10 s), there is an unmet need for sustained delivery systems to enhance efficacy and reduce side effects. In this article, various adenosine delivery techniques, including encapsulation into biodegradable polymers, cell-based delivery, implantable biomaterials and mechanical-based delivery systems, are critically reviewed and the existing challenges are highlighted.
AB - Adenosine is a naturally occurring purine nucleoside in every cell. Many critical treatments such as modulating irregular heartbeat (arrhythmias), regulation of central nervous system (CNS) activity and inhibiting seizural episodes can be carried out using adenosine. Despite the significant potential therapeutic impact of adenosine and its derivatives, the severe side effects caused by their systemic administration have significantly limited their clinical use. In addition, due to adenosines extremely short half-life in human blood (<10 s), there is an unmet need for sustained delivery systems to enhance efficacy and reduce side effects. In this article, various adenosine delivery techniques, including encapsulation into biodegradable polymers, cell-based delivery, implantable biomaterials and mechanical-based delivery systems, are critically reviewed and the existing challenges are highlighted.
KW - Adenosine
KW - controlled drug delivery
KW - controlled release
KW - drug delivery
KW - drug targeting
KW - nanoparticles
KW - targeted drug delivery
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U2 - 10.3109/1061186X.2015.1058803
DO - 10.3109/1061186X.2015.1058803
M3 - Review article
C2 - 26453156
AN - SCOPUS:84944200961
SN - 1061-186X
VL - 23
SP - 580
EP - 596
JO - Journal of Drug Targeting
JF - Journal of Drug Targeting
IS - 7-8
ER -