Adenosine and Glutamate Signaling in Neuron-Glial Interactions: Implications in Alcoholism and Sleep Disorders

Hyung W. Nam, Sally R. McIver, David J. Hinton, Mahesh M. Thakkar, Youssef Sari, Fiona E. Parkinson, Phillip G. Haydon, Doo Sup Choi

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Recent studies have demonstrated that the function of glia is not restricted to the support of neuronal function. Especially, astrocytes are essential for neuronal activity in the brain. Astrocytes actively participate in synapse formation and brain information processing by releasing or uptaking gliotransmitters such as glutamate, d-serine, adenosine 5′-triphosphate (ATP), and adenosine. In the central nervous system, adenosine plays an important role in regulating neuronal activity as well as in controlling other neurotransmitter systems such as GABA, glutamate, and dopamine. Ethanol (EtOH) increases extracellular adenosine levels, which regulates the ataxic and hypnotic/sedative (somnogenic) effects of EtOH. Adenosine signaling is also involved in the homeostasis of major inhibitory/excitatory neurotransmission (i.e., GABA or glutamate) through neuron-glial interactions, which regulates the effect of EtOH and sleep. Adenosine transporters or astrocytic SNARE-mediated transmitter release regulates extracellular or synaptic adenosine levels. Adenosine then exerts its function through several adenosine receptors and regulates glutamate levels in the brain. This review presents novel findings on how neuron-glial interactions, particularly adenosinergic signaling and glutamate uptake activity involving glutamate transporter 1 (GLT1), are implicated in alcoholism and sleep disorders.

Original languageEnglish (US)
Pages (from-to)1117-1125
Number of pages9
JournalAlcoholism: Clinical and Experimental Research
Volume36
Issue number7
DOIs
StatePublished - Jul 2012

Fingerprint

Neuroglia
Adenosine
Alcoholism
Neurons
Glutamic Acid
Brain
Hypnotics and Sedatives
Astrocytes
gamma-Aminobutyric Acid
Amino Acid Transport System X-AG
SNARE Proteins
Purinergic P1 Receptors
Neurology
Automatic Data Processing
Synaptic Transmission
Synapses
Serine
Neurotransmitter Agents
Sleep Wake Disorders
Sleep

Keywords

  • Adenosine
  • Alcoholism
  • Glutamate
  • Pharmacology
  • Signaling
  • Sleep

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Toxicology

Cite this

Adenosine and Glutamate Signaling in Neuron-Glial Interactions : Implications in Alcoholism and Sleep Disorders. / Nam, Hyung W.; McIver, Sally R.; Hinton, David J.; Thakkar, Mahesh M.; Sari, Youssef; Parkinson, Fiona E.; Haydon, Phillip G.; Choi, Doo Sup.

In: Alcoholism: Clinical and Experimental Research, Vol. 36, No. 7, 07.2012, p. 1117-1125.

Research output: Contribution to journalArticle

Nam, Hyung W. ; McIver, Sally R. ; Hinton, David J. ; Thakkar, Mahesh M. ; Sari, Youssef ; Parkinson, Fiona E. ; Haydon, Phillip G. ; Choi, Doo Sup. / Adenosine and Glutamate Signaling in Neuron-Glial Interactions : Implications in Alcoholism and Sleep Disorders. In: Alcoholism: Clinical and Experimental Research. 2012 ; Vol. 36, No. 7. pp. 1117-1125.
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