Adenomyosis demonstrates increased expression of the basic fibroblast growth factor receptor/ligand system compared with autologous endometrium

Anthony M. Propst, Bradley J. Quade, Antonio R. Gargiulo, Romana A. Nowak, Elizabeth A. Stewart

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Objectives: Basic fibroblast growth factor (bFGF) is an angiogenic growth factor present in human endometrium and myometrium. Women with leiomyoma-related abnormal uterine bleeding have local dysregulation of bFGF and its type 1 receptor (FGF-R). This study was designed to evaluate if adenomyosis expresses bFGF and FGF-R, and if present, to compare bFGF and FGF-R expression in adenomyosis and autologous endometrium. Design: Menopausal uteri containing endometrium and adenomyosis were analyzed using immunohistochemistry with monoclonal antibodies specific for bFGF, FGF-R, and proliferating cell nuclear antigen (PCNA), a marker of cellular proliferation. The expression and intensity of staining for bFGF, FGF-R, and PCNA were evaluated in the glandular epithelium and stroma of adenomyosis and endometrium. Results: Glandular epithelial staining was significantly greater in adenomyosis compared with autologous endometrium for bFGF and FGF-R. Stromal staining for bFGF and PCNA was significantly increased in adenomyosis compared with autologous endometrium. Conclusions: Upregulation of the bFGF receptor/ligand system and increased cellular proliferation in adenomyosis may contribute to the pathogenesis of abnormal uterine bleeding associated with adenomyosis.

Original languageEnglish (US)
Pages (from-to)368-371
Number of pages4
JournalMenopause
Volume8
Issue number5
DOIs
StatePublished - 2001

Keywords

  • Adenomyosis
  • Basic fibroblast growth factor
  • Basic fibroblast growth factor receptor
  • Cellular proliferation
  • Menopause

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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