Adenomatoid tumors of the pleura

Mark A. Kaplan, Henry D. Tazelaar, Tomayoshi Hayashi, Kenneth R. Schroer, William D. Travis

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

We report two cases of small pleural nodules showing the distinctive histologic appearance of adenomatoid tumor. Both lesions were discovered incidentally during surgery in patients undergoing lung resection for unrelated intrapulmonary masses: lung carcinoma in one case and histoplasmosis in the other. The tumors were composed of a focal proliferation of epithelioid cells forming vacuoles and tubular spaces in a fibrous stroma, as seen in adenomatoid tumors from other sites. The differential diagnosis in both cases included metastatic signet ring cell carcinoma. The mesothelial nature of the lesions was supported by immunohistochemical and ultrastructural evidence. The tumor cells in both cases were positive for cytokeratin but negative for carcinoembryonic antigen and LeuMI. One case was also negative for BER-EP4, B72.3, CD34, and Factor VIII. Electron microscopy in this case demonstrated well-developed basal laminae, desmosomes, and numerous slender microvilli along the luminal surfaces of the tumor cells. Adenomatoid tumors are regarded as a benign variant of mesothelioma. Despite the abundance of mesothelial cells in the pleura, adenomatoid tumors are apparently extremely rare in this location. Separation from malignant lesions such as adenocarcinoma and epithelioid hemangioendothelioma is important.

Original languageEnglish (US)
Pages (from-to)1219-1223
Number of pages5
JournalAmerican Journal of Surgical Pathology
Volume20
Issue number10
DOIs
StatePublished - Oct 1996

Keywords

  • Adenomatoid tumor
  • Benign mesothelioma
  • Electron microscopy
  • Immunohistochemistry
  • Pleural neoplasms

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

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  • Cite this

    Kaplan, M. A., Tazelaar, H. D., Hayashi, T., Schroer, K. R., & Travis, W. D. (1996). Adenomatoid tumors of the pleura. American Journal of Surgical Pathology, 20(10), 1219-1223. https://doi.org/10.1097/00000478-199610000-00007