Adenocarcinoma of the lung is strongly associated with cigarette smoking

Further evidence from a prospective study of women

Ping Yang, James R Cerhan, R. A. Vierkant, Janet E Olson, Celine M Vachon, Paul John Limburg, Alexander Parker, K. E. Anderson, T. A. Sellers

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

In a prospective cohort of 41,836 Iowa women aged 55-69 years with 13 years of follow-up from 1986 through 1998, the authors examined the association between cigarette smoking history and three common histologic subtypes of lung cancer (123 small cell, 115 squamous cell, and 234 adenocarcinoma). Using Cox proportional hazards and additive Poisson regression analysis, they estimated four epidemiologic measures of effect: age-adjusted incidence rate, relative risk, excess risk (or risk difference), and population attributable risk. Of the three major lung cancer subtypes, the excess risk for heavy smokers compared with never smokers was higher for adenocarcinoma (excess risk = 206) than for squamous cell (excess risk = 122) and small cell (excess risk = 104) carcinomas. Adenocarcinoma of the lung is more strongly associated with tobacco smoke exposure than previously recognized.

Original languageEnglish (US)
Pages (from-to)1114-1122
Number of pages9
JournalAmerican Journal of Epidemiology
Volume156
Issue number12
DOIs
StatePublished - Dec 15 2002

Fingerprint

Smoking
Prospective Studies
Adenocarcinoma
Epithelial Cells
Adenocarcinoma of lung
Small Cell Lung Carcinoma
Smoke
Tobacco
Lung Neoplasms
History
Regression Analysis
Carcinoma
Incidence
Population

Keywords

  • Lung neoplasms
  • Neoplasms by histologic type
  • Relative risk
  • Risk assessment
  • Smoking

ASJC Scopus subject areas

  • Epidemiology

Cite this

@article{2722de1c641f45438803a8b5d46fe943,
title = "Adenocarcinoma of the lung is strongly associated with cigarette smoking: Further evidence from a prospective study of women",
abstract = "In a prospective cohort of 41,836 Iowa women aged 55-69 years with 13 years of follow-up from 1986 through 1998, the authors examined the association between cigarette smoking history and three common histologic subtypes of lung cancer (123 small cell, 115 squamous cell, and 234 adenocarcinoma). Using Cox proportional hazards and additive Poisson regression analysis, they estimated four epidemiologic measures of effect: age-adjusted incidence rate, relative risk, excess risk (or risk difference), and population attributable risk. Of the three major lung cancer subtypes, the excess risk for heavy smokers compared with never smokers was higher for adenocarcinoma (excess risk = 206) than for squamous cell (excess risk = 122) and small cell (excess risk = 104) carcinomas. Adenocarcinoma of the lung is more strongly associated with tobacco smoke exposure than previously recognized.",
keywords = "Lung neoplasms, Neoplasms by histologic type, Relative risk, Risk assessment, Smoking",
author = "Ping Yang and Cerhan, {James R} and Vierkant, {R. A.} and Olson, {Janet E} and Vachon, {Celine M} and Limburg, {Paul John} and Alexander Parker and Anderson, {K. E.} and Sellers, {T. A.}",
year = "2002",
month = "12",
day = "15",
doi = "10.1093/aje/kwf153",
language = "English (US)",
volume = "156",
pages = "1114--1122",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "12",

}

TY - JOUR

T1 - Adenocarcinoma of the lung is strongly associated with cigarette smoking

T2 - Further evidence from a prospective study of women

AU - Yang, Ping

AU - Cerhan, James R

AU - Vierkant, R. A.

AU - Olson, Janet E

AU - Vachon, Celine M

AU - Limburg, Paul John

AU - Parker, Alexander

AU - Anderson, K. E.

AU - Sellers, T. A.

PY - 2002/12/15

Y1 - 2002/12/15

N2 - In a prospective cohort of 41,836 Iowa women aged 55-69 years with 13 years of follow-up from 1986 through 1998, the authors examined the association between cigarette smoking history and three common histologic subtypes of lung cancer (123 small cell, 115 squamous cell, and 234 adenocarcinoma). Using Cox proportional hazards and additive Poisson regression analysis, they estimated four epidemiologic measures of effect: age-adjusted incidence rate, relative risk, excess risk (or risk difference), and population attributable risk. Of the three major lung cancer subtypes, the excess risk for heavy smokers compared with never smokers was higher for adenocarcinoma (excess risk = 206) than for squamous cell (excess risk = 122) and small cell (excess risk = 104) carcinomas. Adenocarcinoma of the lung is more strongly associated with tobacco smoke exposure than previously recognized.

AB - In a prospective cohort of 41,836 Iowa women aged 55-69 years with 13 years of follow-up from 1986 through 1998, the authors examined the association between cigarette smoking history and three common histologic subtypes of lung cancer (123 small cell, 115 squamous cell, and 234 adenocarcinoma). Using Cox proportional hazards and additive Poisson regression analysis, they estimated four epidemiologic measures of effect: age-adjusted incidence rate, relative risk, excess risk (or risk difference), and population attributable risk. Of the three major lung cancer subtypes, the excess risk for heavy smokers compared with never smokers was higher for adenocarcinoma (excess risk = 206) than for squamous cell (excess risk = 122) and small cell (excess risk = 104) carcinomas. Adenocarcinoma of the lung is more strongly associated with tobacco smoke exposure than previously recognized.

KW - Lung neoplasms

KW - Neoplasms by histologic type

KW - Relative risk

KW - Risk assessment

KW - Smoking

UR - http://www.scopus.com/inward/record.url?scp=0037114862&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037114862&partnerID=8YFLogxK

U2 - 10.1093/aje/kwf153

DO - 10.1093/aje/kwf153

M3 - Article

VL - 156

SP - 1114

EP - 1122

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 12

ER -