Adeno-associated virus vector integration

David R. Deyle, David W. Russell

Research output: Contribution to journalReview article

89 Scopus citations

Abstract

Adeno-associated virus (AAV) vectors efficiently transduce various cell types and can produce long-term expression of transgenes in vivo. Although AAV vector genomes can persist within cells as episomes, vector integration has been observed in various experimental settings, either at non-homologous sites where DNA damage may have occurred or by homologous recombination. In some cases, integration is essential for the therapeutic or experimental efficacy of AAV vectors. Recently, insertional mutagenesis resulting from the integration of AAV vectors was associated with tumorigenesis in mice, a consideration that may have relevance for certain clinical applications.

Original languageEnglish (US)
Pages (from-to)442-447
Number of pages6
JournalCurrent Opinion in Molecular Therapeutics
Volume11
Issue number4
StatePublished - Aug 1 2009

Keywords

  • Adeno-associated virus
  • Gene integration
  • Homologous recombination
  • Insertional mutagenesis
  • Vector

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pharmacology
  • Drug Discovery
  • Genetics(clinical)

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