ADAM-17: A target to increase chemotherapeutic efficacy in colorectal cancer?

Adam M. Lee, Robert B. Diasio

Research output: Contribution to journalComment/debate

3 Scopus citations


Chemotherapy-induced activation of ADAM-17 results in increased growth factor shedding and activation of growth factor receptor-mediated pro-survival response. Enhanced ADAM-17 activity and HER ligand shedding results in resistance to chemotherapy in CRC. Therapies that decrease ADAM-17 activity in conjunction with current treatments may enhance response rates in advanced CRC patients.

Original languageEnglish (US)
Pages (from-to)3319-3321
Number of pages3
JournalClinical Cancer Research
Issue number13
StatePublished - Jul 1 2010


ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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