ADAM-17

A target to increase chemotherapeutic efficacy in colorectal cancer?

Adam M. Lee, Robert B Diasio

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Chemotherapy-induced activation of ADAM-17 results in increased growth factor shedding and activation of growth factor receptor-mediated pro-survival response. Enhanced ADAM-17 activity and HER ligand shedding results in resistance to chemotherapy in CRC. Therapies that decrease ADAM-17 activity in conjunction with current treatments may enhance response rates in advanced CRC patients.

Original languageEnglish (US)
Pages (from-to)3319-3321
Number of pages3
JournalClinical Cancer Research
Volume16
Issue number13
DOIs
StatePublished - Jul 1 2010

Fingerprint

Colorectal Neoplasms
Drug Therapy
Growth Factor Receptors
Intercellular Signaling Peptides and Proteins
Ligands
Survival
Therapeutics
ADAM17 Protein

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

ADAM-17 : A target to increase chemotherapeutic efficacy in colorectal cancer? / Lee, Adam M.; Diasio, Robert B.

In: Clinical Cancer Research, Vol. 16, No. 13, 01.07.2010, p. 3319-3321.

Research output: Contribution to journalArticle

@article{b89c842ce1f34d02bcbbf382649e7148,
title = "ADAM-17: A target to increase chemotherapeutic efficacy in colorectal cancer?",
abstract = "Chemotherapy-induced activation of ADAM-17 results in increased growth factor shedding and activation of growth factor receptor-mediated pro-survival response. Enhanced ADAM-17 activity and HER ligand shedding results in resistance to chemotherapy in CRC. Therapies that decrease ADAM-17 activity in conjunction with current treatments may enhance response rates in advanced CRC patients.",
author = "Lee, {Adam M.} and Diasio, {Robert B}",
year = "2010",
month = "7",
day = "1",
doi = "10.1158/1078-0432.CCR-10-1059",
language = "English (US)",
volume = "16",
pages = "3319--3321",
journal = "Clinical Cancer Research",
issn = "1078-0432",
publisher = "American Association for Cancer Research Inc.",
number = "13",

}

TY - JOUR

T1 - ADAM-17

T2 - A target to increase chemotherapeutic efficacy in colorectal cancer?

AU - Lee, Adam M.

AU - Diasio, Robert B

PY - 2010/7/1

Y1 - 2010/7/1

N2 - Chemotherapy-induced activation of ADAM-17 results in increased growth factor shedding and activation of growth factor receptor-mediated pro-survival response. Enhanced ADAM-17 activity and HER ligand shedding results in resistance to chemotherapy in CRC. Therapies that decrease ADAM-17 activity in conjunction with current treatments may enhance response rates in advanced CRC patients.

AB - Chemotherapy-induced activation of ADAM-17 results in increased growth factor shedding and activation of growth factor receptor-mediated pro-survival response. Enhanced ADAM-17 activity and HER ligand shedding results in resistance to chemotherapy in CRC. Therapies that decrease ADAM-17 activity in conjunction with current treatments may enhance response rates in advanced CRC patients.

UR - http://www.scopus.com/inward/record.url?scp=77954232250&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954232250&partnerID=8YFLogxK

U2 - 10.1158/1078-0432.CCR-10-1059

DO - 10.1158/1078-0432.CCR-10-1059

M3 - Article

VL - 16

SP - 3319

EP - 3321

JO - Clinical Cancer Research

JF - Clinical Cancer Research

SN - 1078-0432

IS - 13

ER -