Acyclovir-resistant Herpes Simplex Virus Keratouveitis after Penetrating Keratoplasty

Peter L. Sonkin, Keith Baratz, Richard Frothingham, L. Michael Cobo

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Purpose: A case of acyclovir-resistant herpes simplex virus keratouveitis after penetrating keratoplasty is reported. Methods: Resistance to acyclovir was evident clinically and was confirmed by in vitro susceptibility testing. The susceptibility of the herpes simplex isolates to acyclovir and foscarnet was determined by a dye uptake assay that measured cytopathic effect, and thymidine kinase activity was measured by a plaque autoradiography technique. Results: The viral isolate from postoperative day 22 was susceptible to acyclovir and foscarnet, and showed normal thymidine kinase activity. Isolates from postoperative days 29 and 32 (coinciding with deterioration in clinical appearance) were resistant to acyclovir, susceptible to foscarnet, and deficient in thymidine kinase activity. Conclusion: Practitioners should be aware of the potential for the emergence of resistance in this setting; prophylaxis and rational alternate therapies are discussed.

Original languageEnglish (US)
Pages (from-to)1805-1808
Number of pages4
JournalOphthalmology
Volume99
Issue number12
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

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Penetrating Keratoplasty
Acyclovir
Simplexvirus
Foscarnet
Thymidine Kinase
Herpes Simplex
Autoradiography
Coloring Agents

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Acyclovir-resistant Herpes Simplex Virus Keratouveitis after Penetrating Keratoplasty. / Sonkin, Peter L.; Baratz, Keith; Frothingham, Richard; Cobo, L. Michael.

In: Ophthalmology, Vol. 99, No. 12, 01.01.1992, p. 1805-1808.

Research output: Contribution to journalArticle

Sonkin, Peter L. ; Baratz, Keith ; Frothingham, Richard ; Cobo, L. Michael. / Acyclovir-resistant Herpes Simplex Virus Keratouveitis after Penetrating Keratoplasty. In: Ophthalmology. 1992 ; Vol. 99, No. 12. pp. 1805-1808.
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