Acute viral hepatitis superimposed on alcoholic liver cirrhosis

Clinical and histopathologic features

A. Feller, T. Uchida, Jorge Rakela

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Of 20 patients with alcoholic liver cirrhosis and a superimposed episode of acute viral hepatitis, 12 developed encephalopathy or ascites or both. Four died of hepatic failure. Seventeen patients had received blood transfusions within 6 months before the acute hepatitic episode. Two patients were HBsAg-positive; the other 18 were presumptively diagnosed as having non-A, non-B hepatitis. However, hepatitis A virus infection was excluded in only three of the 18 patients. Histologic examination performed in 13 cases disclosed necrotizing inflammatory activity, which is commonly observed in acute viral hepatitis. The distinctive histologic feature was a meager regenerating activity. We conclude that patients with alcoholic cirrhosis complicated by acute viral hepatitis frequently develop hepatic failure and have a high fatality rate (20% in our series).

Original languageEnglish (US)
Pages (from-to)239-246
Number of pages8
JournalLiver
Volume5
Issue number5
StatePublished - 1985
Externally publishedYes

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Alcoholic Liver Cirrhosis
Hepatitis
Liver Failure
Hepatitis A virus
Brain Diseases
Virus Diseases
Hepatitis B Surface Antigens
Ascites
Blood Transfusion

ASJC Scopus subject areas

  • Hepatology

Cite this

Acute viral hepatitis superimposed on alcoholic liver cirrhosis : Clinical and histopathologic features. / Feller, A.; Uchida, T.; Rakela, Jorge.

In: Liver, Vol. 5, No. 5, 1985, p. 239-246.

Research output: Contribution to journalArticle

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