Acute Topiramate Toxicity

Stephen J. Traub, Mary Ann Howland, Robert S. Hoffman, Lewis S. Nelson

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Topiramate (Topamax®) is an anti-epileptic medication for which acute toxicity is infrequently reported. A 5-yr-old girl, not previously taking topiramate, developed neurological symptoms after acute ingestion of this medication. She was intermittently agitated, complained of "not being able to feel anything," demonstrated arching movements of the back, and perseverated upon questioning. Computerized tomography of the head and electroencephalography were both normal, and urine toxicology testing for drugs of abuse was negative. A serum topiramate level was 10.5 mcg/mL, confirming the ingestion. The patient was observed for 24 h, over which time her symptoms completely resolved.

Original languageEnglish (US)
Pages (from-to)987-990
Number of pages4
JournalJournal of Toxicology - Clinical Toxicology
Volume41
Issue number7
DOIs
StatePublished - Dec 1 2003

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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    Traub, S. J., Howland, M. A., Hoffman, R. S., & Nelson, L. S. (2003). Acute Topiramate Toxicity. Journal of Toxicology - Clinical Toxicology, 41(7), 987-990. https://doi.org/10.1081/CLT-120026522