Acute systemic immune activation following conjunctival exposure to staphylococcal enterotoxin B

Govindarajan Rajagopalan, Michele K. Smart, Robin Patel, Chella S. David

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Conjunctival exposure to the Staphylococcus aureus superantigen staphylococcal enterotoxin B (SEB) may occur accidentally, as a result of bioterrorism, or during colonization or infection of the external eye. Using human leukocyte antigen class II transgenic mice, we show for the first time that conjunctival exposure to SEB can cause robust systemic immune activation.

Original languageEnglish (US)
Pages (from-to)6016-6019
Number of pages4
JournalInfection and Immunity
Volume74
Issue number10
DOIs
StatePublished - Oct 2006

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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