Acute respiratory distress syndrome: insights gained from clinical and translational research.

Marija Kojicic, Emir Festic, Ognjen Gajic

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Acute lung injury and its more severe form acute respiratory distress syndrome (ARDS) are characterized by diffuse impairment of alveolocapillary membrane in the settings of different predisposing conditions such as sepsis, trauma and shock. Many intrahospital exposures, including aspiration, delayed resuscitation, high tidal volume mechanical ventilation and non critical use of transfusions may contribute or worsen ARDS. Therapy is targeted to treatment of predisposing condition, life supportive measures and prevention of nosocomial complications. Rigorous adherence to lung-protective mechanical ventilation is critical to prevent ventilator induced lung injury and decrease mortality. Although survival of ARDS patients has improved in the last decades ARDS mortality rates are still high and survivors encounter significant physical and psychological impairments.

Original languageEnglish (US)
Pages (from-to)59-68
Number of pages10
JournalBosnian journal of basic medical sciences / Udruženje basičnih mediciniskih znanosti = Association of Basic Medical Sciences
Volume9 Suppl 1
StatePublished - Oct 2009

ASJC Scopus subject areas

  • Medicine(all)


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