Acute renal failure after treatment with sunitinib in a patient with multiple myeloma

Nelson Leung; Nathan A. Saucier; Steven R. Zeldenrust; Heidi D. Gunderson; Lynn D. Cornell

doi:10.1093/ndtplus/sfp037

Acute renal failure after treatment with sunitinib in a patient with multiple myeloma

Nelson Leung, Nathan A. Saucier, Steven R. Zeldenrust, Heidi D. Gunderson, Lynn D. Cornell

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Sunitinib is a multiple tyrosine kinase receptors inhibitor that is approved for the treatment of advanced renal cell carcinoma. Amongst its targets are fetal liver tyrosine kinase receptor 3 (FLT 3) and vascular endothelial growth factor receptor (VEGFR). Renal toxicity has not been reported from the trials, but several patients have been reported to develop a pre-eclampsia-like syndrome. We report the first case of acute tubular necrosis in a patient with multiple myeloma following treatment with sunitinib.

Original language	English (US)
Pages (from-to)	292-294
Number of pages	3
Journal	NDT Plus
Volume	2
Issue number	4
DOIs	https://doi.org/10.1093/ndtplus/sfp037
State	Published - Aug 2009

Keywords

acute renal failure
drug toxicity
sunitinib

ASJC Scopus subject areas

Nephrology
Transplantation

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10.1093/ndtplus/sfp037

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abstract = "Sunitinib is a multiple tyrosine kinase receptors inhibitor that is approved for the treatment of advanced renal cell carcinoma. Amongst its targets are fetal liver tyrosine kinase receptor 3 (FLT 3) and vascular endothelial growth factor receptor (VEGFR). Renal toxicity has not been reported from the trials, but several patients have been reported to develop a pre-eclampsia-like syndrome. We report the first case of acute tubular necrosis in a patient with multiple myeloma following treatment with sunitinib.",

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AU - Gunderson, Heidi D.

AU - Cornell, Lynn D.

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AB - Sunitinib is a multiple tyrosine kinase receptors inhibitor that is approved for the treatment of advanced renal cell carcinoma. Amongst its targets are fetal liver tyrosine kinase receptor 3 (FLT 3) and vascular endothelial growth factor receptor (VEGFR). Renal toxicity has not been reported from the trials, but several patients have been reported to develop a pre-eclampsia-like syndrome. We report the first case of acute tubular necrosis in a patient with multiple myeloma following treatment with sunitinib.

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KW - sunitinib

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Acute renal failure after treatment with sunitinib in a patient with multiple myeloma

Abstract

Keywords

ASJC Scopus subject areas

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