Acute promyelocytic leukemia with t(15;16;17;19) and unusual fluorescence in situ hybridization pattern with PML and RARA probes

Nazmi Ragheb Kamal, Curtis A. Hanson, Gordon W. Dewald

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

We report a 58-year-old female with typical morphological and clinical features of acute promyelocytic leukemia in whom a complex translocation involving chromosomes 15, 16, 17 and 19 was detected using conventional cytogenetics and fluorescence in situ hybridization (FISH) with chromosome specific paints. RARA-PML fusion was not evident by FISH, but the RARA signal was split in 74.5% of cells. GTL-banding and FISH with probes of PML, RARA and chromosome 15 specific paint raise the possibility of PML-RARA fusion on the abnormal chromosome 19 in the complex translocation. The unusual PML-RARA fusion may be related to this patient's poor response to induction therapy with all-trans-retinoic acid.

Original languageEnglish (US)
Pages (from-to)54-57
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume92
Issue number1
DOIs
StatePublished - Nov 1 1997

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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