Acute promyelocytic leukemia with t(15;16;17;19) and unusual fluorescence in situ hybridization pattern with PML and RARA probes

Nazmi Ragheb Kamal, Curtis A. Hanson, Gordon W. Dewald

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We report a 58-year-old female with typical morphological and clinical features of acute promyelocytic leukemia in whom a complex translocation involving chromosomes 15, 16, 17 and 19 was detected using conventional cytogenetics and fluorescence in situ hybridization (FISH) with chromosome specific paints. RARA-PML fusion was not evident by FISH, but the RARA signal was split in 74.5% of cells. GTL-banding and FISH with probes of PML, RARA and chromosome 15 specific paint raise the possibility of PML-RARA fusion on the abnormal chromosome 19 in the complex translocation. The unusual PML-RARA fusion may be related to this patient's poor response to induction therapy with all-trans-retinoic acid.

Original languageEnglish (US)
Pages (from-to)54-57
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume92
Issue number1
DOIs
StatePublished - Nov 1997

Fingerprint

Acute Promyelocytic Leukemia
Fluorescence In Situ Hybridization
Chromosomes, Human, Pair 19
Chromosomes, Human, Pair 15
Paint
Chromosomes, Human, Pair 16
Tretinoin
Cytogenetics
Chromosomes
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Acute promyelocytic leukemia with t(15;16;17;19) and unusual fluorescence in situ hybridization pattern with PML and RARA probes. / Kamal, Nazmi Ragheb; Hanson, Curtis A.; Dewald, Gordon W.

In: Cancer Genetics and Cytogenetics, Vol. 92, No. 1, 11.1997, p. 54-57.

Research output: Contribution to journalArticle

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