Acute postoperative seizures after frontal lobe cortical resection for intractable partial epilepsy

Simona Tigaran, Gregory D Cascino, Robyn L. McClelland, Elson L. So, W. Richard Marsh

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Purpose: To evaluate the incidence and prognostic importance of acute postoperative seizures (APOSs) occurring in the first week after a focal corticectomy in patients with partial epilepsy of frontal lobe origin. Methods: We retrospectively evaluated 65 patients who underwent a frontal lobe cortical resection for intractable partial epilepsy between April 1987 and December 2000. All patients were followed up for a minimum of 1 year after surgery. Results: APOSs occurred in 17 (26%) patients. None of the following factors was shown to be significantly associated with the occurrence of APOSs: gender, duration of epilepsy, etiology for seizure disorder, use of subdural or depth electrodes, surgical pathology, or postoperative risk factor for seizures. Patients with APOSs were older at seizure onset and at the time of surgery (p=0.003 and p=0.05, respectively). At last follow-up, patients who had APOSs had a seizure-free outcome similar to that of individuals without APOSs (47.1% vs. 50.0%; p=0.77). Patients with APOSs appeared less likely to have a favorable outcome [i.e., fewer than three seizures per year and >95% decrease in seizure activity (58.8 vs. 70.8%; p=0.35)]. This result may not have reached statistical significance because of the sample size. No evidence suggested that precipitating factors or the timing of APOSs was an important prognostic factor. Conclusions: The presence of APOSs after frontal lobe surgery for intractable epilepsy does not preclude a significant reduction in seizure tendency. These findings may be useful in counseling patients who undergo surgical treatment for frontal lobe epilepsy.

Original languageEnglish (US)
Pages (from-to)831-835
Number of pages5
JournalEpilepsia
Volume44
Issue number6
DOIs
StatePublished - Jun 1 2003

Fingerprint

Partial Epilepsy
Frontal Lobe
Seizures
Drug Resistant Epilepsy
Epilepsy
Frontal Lobe Epilepsy
Precipitating Factors
Surgical Pathology
Sample Size

Keywords

  • Frontal lobe epilepsy
  • Surgical treatment

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Acute postoperative seizures after frontal lobe cortical resection for intractable partial epilepsy. / Tigaran, Simona; Cascino, Gregory D; McClelland, Robyn L.; So, Elson L.; Marsh, W. Richard.

In: Epilepsia, Vol. 44, No. 6, 01.06.2003, p. 831-835.

Research output: Contribution to journalArticle

Tigaran, Simona ; Cascino, Gregory D ; McClelland, Robyn L. ; So, Elson L. ; Marsh, W. Richard. / Acute postoperative seizures after frontal lobe cortical resection for intractable partial epilepsy. In: Epilepsia. 2003 ; Vol. 44, No. 6. pp. 831-835.
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