TY - JOUR
T1 - Acute-on-Chronic Liver Failure
T2 - Can We Agree on a Definition?
AU - Simonetto, Douglas
AU - Kamath, Patrick Sequeira
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Acute-on-chronic liver failure (ACLF) has recently received more recognition. It is a condition characterized by acute clinical deterioration in patients with chronic liver disease and is often associated with a precipitant event. It is a form of decompensated cirrhosis characterized by the presence of extrahepatic organ failure and high short-term mortality. Several definitions have been recently proposed for ACLF; however, larger prospective studies are still needed to refine our understanding of this new entity. This article explores the most recently proposed definitions, classification, and prognostic models of ACLF.
AB - Acute-on-chronic liver failure (ACLF) has recently received more recognition. It is a condition characterized by acute clinical deterioration in patients with chronic liver disease and is often associated with a precipitant event. It is a form of decompensated cirrhosis characterized by the presence of extrahepatic organ failure and high short-term mortality. Several definitions have been recently proposed for ACLF; however, larger prospective studies are still needed to refine our understanding of this new entity. This article explores the most recently proposed definitions, classification, and prognostic models of ACLF.
KW - Cirrhosis
KW - Hepatic decompensation
KW - Liver failure
KW - Multiorgan failure
UR - http://www.scopus.com/inward/record.url?scp=84973562604&partnerID=8YFLogxK
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U2 - 10.1007/s11901-015-0254-x
DO - 10.1007/s11901-015-0254-x
M3 - Review article
AN - SCOPUS:84973562604
VL - 14
SP - 40
EP - 45
JO - Current Hepatitis Reports
JF - Current Hepatitis Reports
SN - 1540-3416
IS - 1
ER -