Acute-on-Chronic Liver Failure: Can We Agree on a Definition?

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Acute-on-chronic liver failure (ACLF) has recently received more recognition. It is a condition characterized by acute clinical deterioration in patients with chronic liver disease and is often associated with a precipitant event. It is a form of decompensated cirrhosis characterized by the presence of extrahepatic organ failure and high short-term mortality. Several definitions have been recently proposed for ACLF; however, larger prospective studies are still needed to refine our understanding of this new entity. This article explores the most recently proposed definitions, classification, and prognostic models of ACLF.

Original languageEnglish (US)
Pages (from-to)40-45
Number of pages6
JournalCurrent Hepatitis Reports
Issue number1
StatePublished - Jan 1 2015


  • Cirrhosis
  • Hepatic decompensation
  • Liver failure
  • Multiorgan failure

ASJC Scopus subject areas

  • Hepatology
  • Virology


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