Acute-on chronic liver failure

Rajiv Jalan, Pere Gines, Jody C. Olson, Rajeshwar P. Mookerjee, Richard Moreau, Guadalupe Garcia-Tsao, Vicente Arroyo, Patrick Sequeira Kamath

Research output: Contribution to journalArticle

345 Citations (Scopus)

Abstract

Acute-on-chronic liver failure (ACLF) is an increasingly recognised entity encompassing an acute deterioration of liver function in patients with cirrhosis, which is usually associated with a precipitating event and results in the failure of one or more organs and high short term mortality. Prospective data to define this is lacking but there is a large body of circumstantial evidence suggesting that this condition is a distinct clinical entity. From the pathophysiologic perspective, altered host response to injury and infection play important roles in its development. This review focuses upon the current understanding of this syndrome from the clinical, prognostic and pathophysiologic perspectives and indicates potential biomarkers and therapeutic targets for intervention.

Original languageEnglish (US)
Pages (from-to)1336-1348
Number of pages13
JournalJournal of Hepatology
Volume57
Issue number6
DOIs
StatePublished - Dec 2012

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Fibrosis
Biomarkers
Mortality
Liver
Wounds and Injuries
Infection
Therapeutics
Acute-On-Chronic Liver Failure

Keywords

  • Acute-on chronic liver failure
  • Hepatic encephalopathy
  • Hepatorenal syndrome
  • Immune failure
  • Liver support
  • Liver transplantation

ASJC Scopus subject areas

  • Hepatology

Cite this

Jalan, R., Gines, P., Olson, J. C., Mookerjee, R. P., Moreau, R., Garcia-Tsao, G., ... Kamath, P. S. (2012). Acute-on chronic liver failure. Journal of Hepatology, 57(6), 1336-1348. https://doi.org/10.1016/j.jhep.2012.06.026

Acute-on chronic liver failure. / Jalan, Rajiv; Gines, Pere; Olson, Jody C.; Mookerjee, Rajeshwar P.; Moreau, Richard; Garcia-Tsao, Guadalupe; Arroyo, Vicente; Kamath, Patrick Sequeira.

In: Journal of Hepatology, Vol. 57, No. 6, 12.2012, p. 1336-1348.

Research output: Contribution to journalArticle

Jalan, R, Gines, P, Olson, JC, Mookerjee, RP, Moreau, R, Garcia-Tsao, G, Arroyo, V & Kamath, PS 2012, 'Acute-on chronic liver failure', Journal of Hepatology, vol. 57, no. 6, pp. 1336-1348. https://doi.org/10.1016/j.jhep.2012.06.026
Jalan R, Gines P, Olson JC, Mookerjee RP, Moreau R, Garcia-Tsao G et al. Acute-on chronic liver failure. Journal of Hepatology. 2012 Dec;57(6):1336-1348. https://doi.org/10.1016/j.jhep.2012.06.026
Jalan, Rajiv ; Gines, Pere ; Olson, Jody C. ; Mookerjee, Rajeshwar P. ; Moreau, Richard ; Garcia-Tsao, Guadalupe ; Arroyo, Vicente ; Kamath, Patrick Sequeira. / Acute-on chronic liver failure. In: Journal of Hepatology. 2012 ; Vol. 57, No. 6. pp. 1336-1348.
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