Acute Myocardial Infarction With Hyperoxemic Therapy (AMIHOT). A Prospective, Randomized Trial of Intracoronary Hyperoxemic Reperfusion After Percutaneous Coronary Intervention

William W. O'Neill, Jack L. Martin, Simon R. Dixon, Antonio L. Bartorelli, Daniela Trabattoni, Pranobe V. Oemrawsingh, Douwe E. Atsma, Michael Chang, William Marquardt, Jae K. Oh, Mitchell W. Krucoff, Raymond J. Gibbons, J. Richard Spears

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

Objectives: This study sought to determine whether hyperoxemic reperfusion with aqueous oxygen (AO) improves recovery of ventricular function after percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI). Background: Hyperbaric oxygen reduces myocardial injury and improves ventricular function when administered during ischemia-reperfusion. Methods: In a prospective, multicenter study, 269 patients with acute anterior or large inferior AMI undergoing primary or rescue PCI (<24 h from symptom onset) were randomly assigned after successful PCI to receive hyperoxemic reperfusion (treatment group) or normoxemic blood autoreperfusion (control group). Hyperoxemic reperfusion was performed for 90 min using intracoronary AO. The primary end points were final infarct size at 14 days, ST-segment resolution, and Δ regional wall motion score index of the infarct zone at 3 months. Results: At 30 days, the incidence of major adverse cardiac events was similar between the control and AO groups (5.2% vs. 6.7%, p = 0.62). There was no significant difference in the incidence of the primary end points between the study groups. In post-hoc analysis, anterior AMI patients reperfused <6 h who were treated with AO had a greater improvement in regional wall motion (Δ wall motion score index = 0.54 in control group vs. 0.75 in AO group, p = 0.03), smaller infarct size (23% of left ventricle in control group vs. 9% of left ventricle in AO group, p = 0.04), and improved ST-segment resolution compared with normoxemic controls. Conclusions: Intracoronary hyperoxemic reperfusion was safe and well tolerated after PCI for AMI, but did not improve regional wall motion, ST-segment resolution, or final infarct size. A possible treatment effect was observed in anterior AMI patients reperfused <6 h of symptom onset.

Original languageEnglish (US)
Pages (from-to)397-405
Number of pages9
JournalJournal of the American College of Cardiology
Volume50
Issue number5
DOIs
StatePublished - Jul 31 2007

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    O'Neill, W. W., Martin, J. L., Dixon, S. R., Bartorelli, A. L., Trabattoni, D., Oemrawsingh, P. V., Atsma, D. E., Chang, M., Marquardt, W., Oh, J. K., Krucoff, M. W., Gibbons, R. J., & Spears, J. R. (2007). Acute Myocardial Infarction With Hyperoxemic Therapy (AMIHOT). A Prospective, Randomized Trial of Intracoronary Hyperoxemic Reperfusion After Percutaneous Coronary Intervention. Journal of the American College of Cardiology, 50(5), 397-405. https://doi.org/10.1016/j.jacc.2007.01.099