Acute Myocardial Infarction in Young Individuals

Rajiv Gulati, Atta Behfar, Jagat Narula, Ardaas Kanwar, Amir Lerman, Leslie Cooper, Mandeep Singh

Research output: Contribution to journalReview article

Abstract

Globally, cardiovascular disease remains a major cause of adverse outcomes in young individuals, unlike its decline in other age groups. This group is not well studied and has a unique risk profile with less traditional cardiovascular risk factors compared with older populations. Plaque rupture still remains the most common etiology of myocardial infarction, but unique syndromes such as plaque erosion, coronary microvascular dysfunction, spontaneous coronary artery dissection, and coronary spasm related to drug use are more prevalent in this age group. Such diversity of diagnosis and presentation, along with therapeutic implications, underscore the need to study the profile of myocardial infarction in young persons. We searched PubMed for articles published from 1980 to 218 using the terms acute myocardial infarction, young, plaque rupture, plaque erosion, spontaneous coronary artery dissection (SCAD), coronary vasospasm, variant or Prinzmetal angina, drug-induced myocardial infarction, myocarditis, coronary embolism, microvascular dysfunction, MINOCA, and myocardial infarction in pregnancy and reviewed all the published studies. With the data from this search, we aim to inform readers of the prevalence, risk factors, presentation, and management of acute myocardial infarction in young patients and elaborate on special subgroups with diagnostic and therapeutic challenges. We also outline a parsimonious method designed to simplify management of these complex patients.

Original languageEnglish (US)
Pages (from-to)136-156
Number of pages21
JournalMayo Clinic proceedings
Volume95
Issue number1
DOIs
StatePublished - Jan 2020

Fingerprint

Myocardial Infarction
Rupture
Age Groups
Coronary Vasospasm
Myocarditis
Risk Management
Spasm
Embolism
PubMed
Pharmaceutical Preparations
Cardiovascular Diseases
Pregnancy
Therapeutics
Population
Spontaneous Coronary Artery Dissection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Acute Myocardial Infarction in Young Individuals. / Gulati, Rajiv; Behfar, Atta; Narula, Jagat; Kanwar, Ardaas; Lerman, Amir; Cooper, Leslie; Singh, Mandeep.

In: Mayo Clinic proceedings, Vol. 95, No. 1, 01.2020, p. 136-156.

Research output: Contribution to journalReview article

Gulati, Rajiv ; Behfar, Atta ; Narula, Jagat ; Kanwar, Ardaas ; Lerman, Amir ; Cooper, Leslie ; Singh, Mandeep. / Acute Myocardial Infarction in Young Individuals. In: Mayo Clinic proceedings. 2020 ; Vol. 95, No. 1. pp. 136-156.
@article{4b377fd1fb3445e6be41f8eacf1988ed,
title = "Acute Myocardial Infarction in Young Individuals",
abstract = "Globally, cardiovascular disease remains a major cause of adverse outcomes in young individuals, unlike its decline in other age groups. This group is not well studied and has a unique risk profile with less traditional cardiovascular risk factors compared with older populations. Plaque rupture still remains the most common etiology of myocardial infarction, but unique syndromes such as plaque erosion, coronary microvascular dysfunction, spontaneous coronary artery dissection, and coronary spasm related to drug use are more prevalent in this age group. Such diversity of diagnosis and presentation, along with therapeutic implications, underscore the need to study the profile of myocardial infarction in young persons. We searched PubMed for articles published from 1980 to 218 using the terms acute myocardial infarction, young, plaque rupture, plaque erosion, spontaneous coronary artery dissection (SCAD), coronary vasospasm, variant or Prinzmetal angina, drug-induced myocardial infarction, myocarditis, coronary embolism, microvascular dysfunction, MINOCA, and myocardial infarction in pregnancy and reviewed all the published studies. With the data from this search, we aim to inform readers of the prevalence, risk factors, presentation, and management of acute myocardial infarction in young patients and elaborate on special subgroups with diagnostic and therapeutic challenges. We also outline a parsimonious method designed to simplify management of these complex patients.",
author = "Rajiv Gulati and Atta Behfar and Jagat Narula and Ardaas Kanwar and Amir Lerman and Leslie Cooper and Mandeep Singh",
year = "2020",
month = "1",
doi = "10.1016/j.mayocp.2019.05.001",
language = "English (US)",
volume = "95",
pages = "136--156",
journal = "Mayo Clinic Proceedings",
issn = "0025-6196",
publisher = "Elsevier Science",
number = "1",

}

TY - JOUR

T1 - Acute Myocardial Infarction in Young Individuals

AU - Gulati, Rajiv

AU - Behfar, Atta

AU - Narula, Jagat

AU - Kanwar, Ardaas

AU - Lerman, Amir

AU - Cooper, Leslie

AU - Singh, Mandeep

PY - 2020/1

Y1 - 2020/1

N2 - Globally, cardiovascular disease remains a major cause of adverse outcomes in young individuals, unlike its decline in other age groups. This group is not well studied and has a unique risk profile with less traditional cardiovascular risk factors compared with older populations. Plaque rupture still remains the most common etiology of myocardial infarction, but unique syndromes such as plaque erosion, coronary microvascular dysfunction, spontaneous coronary artery dissection, and coronary spasm related to drug use are more prevalent in this age group. Such diversity of diagnosis and presentation, along with therapeutic implications, underscore the need to study the profile of myocardial infarction in young persons. We searched PubMed for articles published from 1980 to 218 using the terms acute myocardial infarction, young, plaque rupture, plaque erosion, spontaneous coronary artery dissection (SCAD), coronary vasospasm, variant or Prinzmetal angina, drug-induced myocardial infarction, myocarditis, coronary embolism, microvascular dysfunction, MINOCA, and myocardial infarction in pregnancy and reviewed all the published studies. With the data from this search, we aim to inform readers of the prevalence, risk factors, presentation, and management of acute myocardial infarction in young patients and elaborate on special subgroups with diagnostic and therapeutic challenges. We also outline a parsimonious method designed to simplify management of these complex patients.

AB - Globally, cardiovascular disease remains a major cause of adverse outcomes in young individuals, unlike its decline in other age groups. This group is not well studied and has a unique risk profile with less traditional cardiovascular risk factors compared with older populations. Plaque rupture still remains the most common etiology of myocardial infarction, but unique syndromes such as plaque erosion, coronary microvascular dysfunction, spontaneous coronary artery dissection, and coronary spasm related to drug use are more prevalent in this age group. Such diversity of diagnosis and presentation, along with therapeutic implications, underscore the need to study the profile of myocardial infarction in young persons. We searched PubMed for articles published from 1980 to 218 using the terms acute myocardial infarction, young, plaque rupture, plaque erosion, spontaneous coronary artery dissection (SCAD), coronary vasospasm, variant or Prinzmetal angina, drug-induced myocardial infarction, myocarditis, coronary embolism, microvascular dysfunction, MINOCA, and myocardial infarction in pregnancy and reviewed all the published studies. With the data from this search, we aim to inform readers of the prevalence, risk factors, presentation, and management of acute myocardial infarction in young patients and elaborate on special subgroups with diagnostic and therapeutic challenges. We also outline a parsimonious method designed to simplify management of these complex patients.

UR - http://www.scopus.com/inward/record.url?scp=85076853138&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85076853138&partnerID=8YFLogxK

U2 - 10.1016/j.mayocp.2019.05.001

DO - 10.1016/j.mayocp.2019.05.001

M3 - Review article

C2 - 31902409

AN - SCOPUS:85076853138

VL - 95

SP - 136

EP - 156

JO - Mayo Clinic Proceedings

JF - Mayo Clinic Proceedings

SN - 0025-6196

IS - 1

ER -