Acute myelogenous leukemia in an adult with thrombocytopenia with absent radii syndrome

Ronald S. Go, Kaye L. Johnston

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Acute myelogenous leukemia with t(8;21)(q22;q22) developed in a 42-yr-old woman having thrombocytopenia with absent radii syndrome (TARS). Standard induction and postremission therapies were safely administered. With each successive chemotherapy, the onset of platelet recovery was not delayed, but peak platelet counts were persistently suppressed. Nine months after achieving complete hematologic and cytogenetic remission, she remains severely thrombocytopenic (platelet count 6-12 × 109/L). She is, however, asymptomatic and transfusion independent. Of interest is the transient normalization of platelet count (rebound relative thrombocytosis). Our report and review of the literature suggests that TARS, contrary to previous belief, may be associated with increased risk of acute leukemia.

Original languageEnglish (US)
Pages (from-to)246-248
Number of pages3
JournalEuropean Journal of Haematology
Volume70
Issue number4
DOIs
StatePublished - Apr 1 2003
Externally publishedYes

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Keywords

  • Acute myelogenous leukemia
  • Rebound relative thrombocytosis
  • Thrombocytopenia with absent radii syndrome

ASJC Scopus subject areas

  • Hematology

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