Acute lymphocytic leukemia with eosinophilia: Two case reports and a literature review

Floranne Wilson, Ayalew Tefferi

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Acute lymphocytic leukemia (ALL) associated with eosinophilia is a rare occurrence, but a distinct clinicopathological entity. There have been approximately 44 cases reported in the world literature to date. We report 2 previously healthy young men, aged 20 and 32 years, who presented with marked eosinophilia, and were later diagnosed with pre-B ALL. The patients suffered from significant complications related to eosinophil toxicity, including respiratory failure, myocardial infarction, and a cerebrovascular accident during initial hospitalization. They were treated with high-dose steroids resulting in a rapid suppression of the eosinophilia. Both patients also received chemotherapy according to the standard protocol for ALL; unfortunately, case 1 expired within 2 years of diagnosis from complications related to sepsis and multi-organ failure. We also review the literature and compare the demographics, clinical features, and outcomes of several case studies reported.

Original languageEnglish (US)
Pages (from-to)1045-1050
Number of pages6
JournalLeukemia and Lymphoma
Volume46
Issue number7
DOIs
StatePublished - 2005

Fingerprint

Eosinophilia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
B-Cell Leukemia
Eosinophils
Respiratory Insufficiency
Sepsis
Hospitalization
Stroke
Steroids
Myocardial Infarction
Demography
Drug Therapy

Keywords

  • Acute lymphocytic leukemia
  • Eosinophils
  • Literature review
  • Steroids

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Acute lymphocytic leukemia with eosinophilia : Two case reports and a literature review. / Wilson, Floranne; Tefferi, Ayalew.

In: Leukemia and Lymphoma, Vol. 46, No. 7, 2005, p. 1045-1050.

Research output: Contribution to journalArticle

@article{32900b9560bf462fb4884fe40a038f4a,
title = "Acute lymphocytic leukemia with eosinophilia: Two case reports and a literature review",
abstract = "Acute lymphocytic leukemia (ALL) associated with eosinophilia is a rare occurrence, but a distinct clinicopathological entity. There have been approximately 44 cases reported in the world literature to date. We report 2 previously healthy young men, aged 20 and 32 years, who presented with marked eosinophilia, and were later diagnosed with pre-B ALL. The patients suffered from significant complications related to eosinophil toxicity, including respiratory failure, myocardial infarction, and a cerebrovascular accident during initial hospitalization. They were treated with high-dose steroids resulting in a rapid suppression of the eosinophilia. Both patients also received chemotherapy according to the standard protocol for ALL; unfortunately, case 1 expired within 2 years of diagnosis from complications related to sepsis and multi-organ failure. We also review the literature and compare the demographics, clinical features, and outcomes of several case studies reported.",
keywords = "Acute lymphocytic leukemia, Eosinophils, Literature review, Steroids",
author = "Floranne Wilson and Ayalew Tefferi",
year = "2005",
doi = "10.1080/10428190500085537",
language = "English (US)",
volume = "46",
pages = "1045--1050",
journal = "Leukemia and Lymphoma",
issn = "1042-8194",
publisher = "Informa Healthcare",
number = "7",

}

TY - JOUR

T1 - Acute lymphocytic leukemia with eosinophilia

T2 - Two case reports and a literature review

AU - Wilson, Floranne

AU - Tefferi, Ayalew

PY - 2005

Y1 - 2005

N2 - Acute lymphocytic leukemia (ALL) associated with eosinophilia is a rare occurrence, but a distinct clinicopathological entity. There have been approximately 44 cases reported in the world literature to date. We report 2 previously healthy young men, aged 20 and 32 years, who presented with marked eosinophilia, and were later diagnosed with pre-B ALL. The patients suffered from significant complications related to eosinophil toxicity, including respiratory failure, myocardial infarction, and a cerebrovascular accident during initial hospitalization. They were treated with high-dose steroids resulting in a rapid suppression of the eosinophilia. Both patients also received chemotherapy according to the standard protocol for ALL; unfortunately, case 1 expired within 2 years of diagnosis from complications related to sepsis and multi-organ failure. We also review the literature and compare the demographics, clinical features, and outcomes of several case studies reported.

AB - Acute lymphocytic leukemia (ALL) associated with eosinophilia is a rare occurrence, but a distinct clinicopathological entity. There have been approximately 44 cases reported in the world literature to date. We report 2 previously healthy young men, aged 20 and 32 years, who presented with marked eosinophilia, and were later diagnosed with pre-B ALL. The patients suffered from significant complications related to eosinophil toxicity, including respiratory failure, myocardial infarction, and a cerebrovascular accident during initial hospitalization. They were treated with high-dose steroids resulting in a rapid suppression of the eosinophilia. Both patients also received chemotherapy according to the standard protocol for ALL; unfortunately, case 1 expired within 2 years of diagnosis from complications related to sepsis and multi-organ failure. We also review the literature and compare the demographics, clinical features, and outcomes of several case studies reported.

KW - Acute lymphocytic leukemia

KW - Eosinophils

KW - Literature review

KW - Steroids

UR - http://www.scopus.com/inward/record.url?scp=22144485985&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22144485985&partnerID=8YFLogxK

U2 - 10.1080/10428190500085537

DO - 10.1080/10428190500085537

M3 - Article

C2 - 16019556

AN - SCOPUS:22144485985

VL - 46

SP - 1045

EP - 1050

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

SN - 1042-8194

IS - 7

ER -