TY - JOUR
T1 - Acute lymphocytic leukemia with eosinophilia
T2 - Two case reports and a literature review
AU - Wilson, Floranne
AU - Tefferi, Ayalew
PY - 2005
Y1 - 2005
N2 - Acute lymphocytic leukemia (ALL) associated with eosinophilia is a rare occurrence, but a distinct clinicopathological entity. There have been approximately 44 cases reported in the world literature to date. We report 2 previously healthy young men, aged 20 and 32 years, who presented with marked eosinophilia, and were later diagnosed with pre-B ALL. The patients suffered from significant complications related to eosinophil toxicity, including respiratory failure, myocardial infarction, and a cerebrovascular accident during initial hospitalization. They were treated with high-dose steroids resulting in a rapid suppression of the eosinophilia. Both patients also received chemotherapy according to the standard protocol for ALL; unfortunately, case 1 expired within 2 years of diagnosis from complications related to sepsis and multi-organ failure. We also review the literature and compare the demographics, clinical features, and outcomes of several case studies reported.
AB - Acute lymphocytic leukemia (ALL) associated with eosinophilia is a rare occurrence, but a distinct clinicopathological entity. There have been approximately 44 cases reported in the world literature to date. We report 2 previously healthy young men, aged 20 and 32 years, who presented with marked eosinophilia, and were later diagnosed with pre-B ALL. The patients suffered from significant complications related to eosinophil toxicity, including respiratory failure, myocardial infarction, and a cerebrovascular accident during initial hospitalization. They were treated with high-dose steroids resulting in a rapid suppression of the eosinophilia. Both patients also received chemotherapy according to the standard protocol for ALL; unfortunately, case 1 expired within 2 years of diagnosis from complications related to sepsis and multi-organ failure. We also review the literature and compare the demographics, clinical features, and outcomes of several case studies reported.
KW - Acute lymphocytic leukemia
KW - Eosinophils
KW - Literature review
KW - Steroids
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U2 - 10.1080/10428190500085537
DO - 10.1080/10428190500085537
M3 - Article
C2 - 16019556
AN - SCOPUS:22144485985
SN - 1042-8194
VL - 46
SP - 1045
EP - 1050
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 7
ER -