Acute leukemia in pregnancy: a single institution experience with 23 patients

Nosha Farhadfar, Sonia Cerquozzi, Michael R. Hessenauer, Mark R Litzow, William Hogan, Louis Letendre, Mrinal M Patnaik, Ayalew Tefferi, Naseema Gangat

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Management of acute leukemia during pregnancy presents a considerable challenge. Herein, we review our experience of 23 patients diagnosed with acute leukemia; during pregnancy at the Mayo Clinic between 1962 and 2016. Ten (43.4%), seven (30.4%), and six (26.2%) patients were diagnosed in first, second, and third trimester, respectively. In approximately, 50% (n = 11) therapeutic terminations or spontaneous abortions occurred. Fifty percent (2/4) of patients diagnosed during either first or second trimester who delayed chemotherapy by greater than one week died during induction therapy. Eleven patients received chemotherapy while pregnant which led to four fetal losses and seven deliveries (five full-term and two preterm deliveries). No congenital malformations were reported. Eighteen patients (78%) achieved complete remission. At a median follow up of 55 months, seven patients (30%) remain alive. In summary, we provide a comprehensive description of maternal and fetal outcomes and insight into management of acute leukemia during pregnancy.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalLeukemia and Lymphoma
DOIs
StateAccepted/In press - Aug 25 2016

Keywords

  • Acute leukemia
  • chemotherapy
  • pregnancy

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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