Acute kidney injury following total joint arthroplasty: Retrospective analysis

Toby N. Weingarten, Carmelina Gurrieri, Paul D. Jarett, Deforest R. Brown, Novette J. Berntson, Reynaldo D. Calaro, Daryl J Kor, Daniel J. Berry, Vesna D Garovic, Wayne T. Nicholson, Darrell R. Schroeder, Juraj Sprung

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Abstract

Introduction: Postoperative acute kidney injury (AKI) following arthroplasty has not been well studied. Our aim was to identify factors associated with increased risk of AKI. Methods: The medical records for adult patients who underwent elective total joint arthroplasty during June 1, 2007 to May 31, 2010 at the Mayo Clinic were reviewed to identify patients with normal preoperative kidney function who experienced perioperative AKI, defined as an increase in serum creatinine (sCr) by 26.4 μmol·L-1. For each AKI case, two controls were identified and matched for age, sex, and type of operation. Medical records were abstracted for demographics, comorbid conditions, and preoperative, intraoperative, and postoperative variables. Conditional logistic regression analyses were performed to identify risk factors for AKI. Results: Of the 9,171 patients who underwent joint replacement operations, 167 with normal preoperative renal function developed AKI with a median [25th, 75th] increase in sCr of 35.4 [26.4, 44.2] μmol·L-1. No patient required dialysis. A higher than normal body mass index, diabetes mellitus, the number of baseline antihypertensive medications, cerebral or peripheral vascular disease, use of general anesthesia, and perioperative blood transfusions were independently associated with risk for AKI. Hospital length of stay and intensive care admissions were greater in AKI patients, and in 12.0% of patients, sCr remained at least 26.4 μmol·L-1 higher than preoperative baseline at least three months after surgery. Conclusion: In this case-control investigation, we identified several factors associated with the development of postoperative AKI. Recognition of these risk factors could allow for the adoption of perioperative renal protective strategies in patients undergoing arthroplasty.

Original languageEnglish (US)
Pages (from-to)1111-1118
Number of pages8
JournalCanadian Journal of Anesthesia
Volume59
Issue number12
DOIs
StatePublished - Dec 2012

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Acute Kidney Injury
Arthroplasty
Joints
Creatinine
Kidney
Medical Records
Length of Stay
Replacement Arthroplasties
Serum
Peripheral Vascular Diseases
Critical Care
Blood Transfusion
General Anesthesia
Antihypertensive Agents
Dialysis
Diabetes Mellitus
Body Mass Index
Logistic Models
Regression Analysis
Demography

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Weingarten, T. N., Gurrieri, C., Jarett, P. D., Brown, D. R., Berntson, N. J., Calaro, R. D., ... Sprung, J. (2012). Acute kidney injury following total joint arthroplasty: Retrospective analysis. Canadian Journal of Anesthesia, 59(12), 1111-1118. https://doi.org/10.1007/s12630-012-9797-2

Acute kidney injury following total joint arthroplasty : Retrospective analysis. / Weingarten, Toby N.; Gurrieri, Carmelina; Jarett, Paul D.; Brown, Deforest R.; Berntson, Novette J.; Calaro, Reynaldo D.; Kor, Daryl J; Berry, Daniel J.; Garovic, Vesna D; Nicholson, Wayne T.; Schroeder, Darrell R.; Sprung, Juraj.

In: Canadian Journal of Anesthesia, Vol. 59, No. 12, 12.2012, p. 1111-1118.

Research output: Contribution to journalArticle

Weingarten, TN, Gurrieri, C, Jarett, PD, Brown, DR, Berntson, NJ, Calaro, RD, Kor, DJ, Berry, DJ, Garovic, VD, Nicholson, WT, Schroeder, DR & Sprung, J 2012, 'Acute kidney injury following total joint arthroplasty: Retrospective analysis', Canadian Journal of Anesthesia, vol. 59, no. 12, pp. 1111-1118. https://doi.org/10.1007/s12630-012-9797-2
Weingarten TN, Gurrieri C, Jarett PD, Brown DR, Berntson NJ, Calaro RD et al. Acute kidney injury following total joint arthroplasty: Retrospective analysis. Canadian Journal of Anesthesia. 2012 Dec;59(12):1111-1118. https://doi.org/10.1007/s12630-012-9797-2
Weingarten, Toby N. ; Gurrieri, Carmelina ; Jarett, Paul D. ; Brown, Deforest R. ; Berntson, Novette J. ; Calaro, Reynaldo D. ; Kor, Daryl J ; Berry, Daniel J. ; Garovic, Vesna D ; Nicholson, Wayne T. ; Schroeder, Darrell R. ; Sprung, Juraj. / Acute kidney injury following total joint arthroplasty : Retrospective analysis. In: Canadian Journal of Anesthesia. 2012 ; Vol. 59, No. 12. pp. 1111-1118.
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AU - Calaro, Reynaldo D.

AU - Kor, Daryl J

AU - Berry, Daniel J.

AU - Garovic, Vesna D

AU - Nicholson, Wayne T.

AU - Schroeder, Darrell R.

AU - Sprung, Juraj

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N2 - Introduction: Postoperative acute kidney injury (AKI) following arthroplasty has not been well studied. Our aim was to identify factors associated with increased risk of AKI. Methods: The medical records for adult patients who underwent elective total joint arthroplasty during June 1, 2007 to May 31, 2010 at the Mayo Clinic were reviewed to identify patients with normal preoperative kidney function who experienced perioperative AKI, defined as an increase in serum creatinine (sCr) by 26.4 μmol·L-1. For each AKI case, two controls were identified and matched for age, sex, and type of operation. Medical records were abstracted for demographics, comorbid conditions, and preoperative, intraoperative, and postoperative variables. Conditional logistic regression analyses were performed to identify risk factors for AKI. Results: Of the 9,171 patients who underwent joint replacement operations, 167 with normal preoperative renal function developed AKI with a median [25th, 75th] increase in sCr of 35.4 [26.4, 44.2] μmol·L-1. No patient required dialysis. A higher than normal body mass index, diabetes mellitus, the number of baseline antihypertensive medications, cerebral or peripheral vascular disease, use of general anesthesia, and perioperative blood transfusions were independently associated with risk for AKI. Hospital length of stay and intensive care admissions were greater in AKI patients, and in 12.0% of patients, sCr remained at least 26.4 μmol·L-1 higher than preoperative baseline at least three months after surgery. Conclusion: In this case-control investigation, we identified several factors associated with the development of postoperative AKI. Recognition of these risk factors could allow for the adoption of perioperative renal protective strategies in patients undergoing arthroplasty.

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