Acute hypoxia and endogenous renal endothelin

Amiram Nir, Alfrede L. Clavell, Denise Heublein, Lawrence L. Aarhus, John C Jr. Burnett

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Endothelin (ET) is a potent vasoconstrictor peptide of endothelial cell origin. Recent studies have suggested a nonvascular paracrine and/or autocrine role for endothelin in the kidney. This study was designed to elucidate the renal ET response to acute moderate hypoxia, as reflected by urinary ET excretory rate and renal tissue ET immunoreactivity, and to correlate these responses to the hemodynamic and excretory changes during hypoxia. Experiments were conducted in two groups of anesthetized dogs: hypoxic group (10% O 2 ventilation: Po 2, 44 mm Hg; N = 7) and time control group (room air ventilation: Po 2, 111 mm Hg; N = 6). After 60 min of hypoxia or room air ventilation, kidneys were harvested and stained immunohistochemically for ET. Acute moderate hypoxia was associated with significant increases in urinary ET excretion, urine flow, urinary sodium excretion, and fractional excretion of sodium (P < 0.05). There was no significant change in GFR, RBF, renal vascular resistance, or mean arterial pressure. Renal immunohistochemistry for ET revealed increased staining in the proximal and distal tubules in the hypoxic group as compared with controls. This study demonstrates that acute moderate hypoxia results in increased urinary ET excretion and renal tubular ET immunoreactivity, in association with diuresis and natriuresis, and suggests a nonvascular role of endogenously produced renal ET in the regulation of sodium homeostasis during hypoxia.

Original languageEnglish (US)
Pages (from-to)1920-1924
Number of pages5
JournalJournal of the American Society of Nephrology
Volume4
Issue number11
StatePublished - May 1994

Fingerprint

Endothelins
Kidney
Ventilation
Sodium
Hypoxia
Air
Natriuresis
Diuresis
Vasoconstrictor Agents
Vascular Resistance
Arterial Pressure
Homeostasis
Endothelial Cells
Hemodynamics
Immunohistochemistry
Urine
Dogs
Staining and Labeling
Control Groups
Peptides

Keywords

  • Endothelin
  • Hypoxia
  • Kidney
  • Urine

ASJC Scopus subject areas

  • Nephrology

Cite this

Nir, A., Clavell, A. L., Heublein, D., Aarhus, L. L., & Burnett, J. C. J. (1994). Acute hypoxia and endogenous renal endothelin. Journal of the American Society of Nephrology, 4(11), 1920-1924.

Acute hypoxia and endogenous renal endothelin. / Nir, Amiram; Clavell, Alfrede L.; Heublein, Denise; Aarhus, Lawrence L.; Burnett, John C Jr.

In: Journal of the American Society of Nephrology, Vol. 4, No. 11, 05.1994, p. 1920-1924.

Research output: Contribution to journalArticle

Nir, A, Clavell, AL, Heublein, D, Aarhus, LL & Burnett, JCJ 1994, 'Acute hypoxia and endogenous renal endothelin', Journal of the American Society of Nephrology, vol. 4, no. 11, pp. 1920-1924.
Nir A, Clavell AL, Heublein D, Aarhus LL, Burnett JCJ. Acute hypoxia and endogenous renal endothelin. Journal of the American Society of Nephrology. 1994 May;4(11):1920-1924.
Nir, Amiram ; Clavell, Alfrede L. ; Heublein, Denise ; Aarhus, Lawrence L. ; Burnett, John C Jr. / Acute hypoxia and endogenous renal endothelin. In: Journal of the American Society of Nephrology. 1994 ; Vol. 4, No. 11. pp. 1920-1924.
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