@article{c689c3be29554ef98252672488f5177b,
title = "Acute hyperosmolar hyperglycemia causes axonal shrinkage and reduced nerve conduction velocity",
abstract = "Cats infused with hypertonic dextrose to increase plasma glucose to values at or above those found in human hyperglycemic hyperosmolar nonketotic coma developed a small but progressive reduction of conduction velocity of A alpha motor fibers during 6 h which was not prevented by the addition of myo-inositol. Axonal shirnkage, probably sufficient to cause the reduction in conduction velocity, and other morphometric features were similar to those produced by hyperosmolar fixation of normal nerve and by streptozotocin diabetes in rats.",
author = "Dyck, {Peter James} and Lambert, {Edward H.} and Windebank, {Anthony J.} and Lais, {Alfred A.} and Sparks, {Margaret F.} and Jeannine Karnes and Sherman, {William R.} and Hallcher, {Loretta M.} and Low, {Phillip A.} and Service, {F. John}",
note = "Funding Information: 1 This work was supported in part by a Peripheral Neuropathy Clinical Center Grant from the National Institutes of Health (NS14304); by a Center Grant from the Muscular Dystrophy Association; by Mayo, Borchard, Upton, and Gallagher Funds; and by the Washington University Diabetes Research and Training Center grant AM20597 and by NSO5159.",
year = "1981",
month = mar,
doi = "10.1016/0014-4886(81)90028-5",
language = "English (US)",
volume = "71",
pages = "507--514",
journal = "Experimental Neurology",
issn = "0014-4886",
publisher = "Academic Press Inc.",
number = "3",
}