Acute hyperosmolar hyperglycemia causes axonal shrinkage and reduced nerve conduction velocity

Peter James Dyck, Edward H. Lambert, Anthony J. Windebank, Alfred A. Lais, Margaret F. Sparks, Jeannine Karnes, William R. Sherman, Loretta M. Hallcher, Phillip A. Low, F. John Service

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Cats infused with hypertonic dextrose to increase plasma glucose to values at or above those found in human hyperglycemic hyperosmolar nonketotic coma developed a small but progressive reduction of conduction velocity of A alpha motor fibers during 6 h which was not prevented by the addition of myo-inositol. Axonal shirnkage, probably sufficient to cause the reduction in conduction velocity, and other morphometric features were similar to those produced by hyperosmolar fixation of normal nerve and by streptozotocin diabetes in rats.

Original languageEnglish (US)
Pages (from-to)507-514
Number of pages8
JournalExperimental Neurology
Volume71
Issue number3
DOIs
StatePublished - Mar 1981

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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    Dyck, P. J., Lambert, E. H., Windebank, A. J., Lais, A. A., Sparks, M. F., Karnes, J., Sherman, W. R., Hallcher, L. M., Low, P. A., & Service, F. J. (1981). Acute hyperosmolar hyperglycemia causes axonal shrinkage and reduced nerve conduction velocity. Experimental Neurology, 71(3), 507-514. https://doi.org/10.1016/0014-4886(81)90028-5