Acute granulomatous interstitial nephritis and colitis in anticonvulsant hypersensitivity syndrome associated with lamotrigine treatment

Fernando C. Fervenza, Kanakiriya Sharan, Robert T. Kunau, Gibney Richard, Donna J. Lager

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

We present the case of a 17-year-old woman with a history of bipolar disorder, who developed a clinical syndrome manifested by fever, lymphadenopathy, skin rash, diarrhea, and acute renal failure requiring dialysis after the use of lamotrigine. Renal biopsy showed acute interstitial nephritis (AIN) with focal granulomas. Similarly, colonic biopsy specimens showed colitis and ileitis with non-necrotizing epithelioid granulomas. The patient had a complete recovery after withdrawal of the medication and steroid treatment. Although lamotrigine has been previously implicated in the development of anticonvulsant hypersensitivity syndrome, there have been no previous reports of acute granulomatous interstitial nephritis or colitis associated with the use of this drug. (C) 2000 by the National Kidney Foundation, Inc.

Original languageEnglish (US)
Pages (from-to)1034-1040
Number of pages7
JournalAmerican Journal of Kidney Diseases
Volume36
Issue number5
DOIs
StatePublished - Jan 1 2000

Keywords

  • Acute renal failure
  • Anticonvulsant hypersensitivity syndrome (AHS)
  • Colitis
  • Granuloma
  • Interstitial nephritis
  • Lamotrigine
  • Valproic acid

ASJC Scopus subject areas

  • Nephrology

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