Acute exposure to GH during exercise stimulates the turnover of free fatty acids in GH-deficient men

Jill A. Kanaley, Rolf Dall, Niels Møller, Sven C. Nielsen, Jens Sandahl Christiansen, Michael Dennis Jensen, Jens Otto Lunde Jørgensen

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The secretion of growth hormone (GH) increases acutely during exercise, but whether this is associated with the concomitant alterations in substrate metabolism has not previously been studied. We examined the effects of acute GH administration on palmitate, glucose, and protein metabolism before, during, and after 45 min of moderate-intensity aerobic exercise in eight GH-deficient men (mean age = 40.8 ± 2.9 yr) on two occasions, with (+GH; 0.4 IU GH) and without GH administered (-GH). A group of healthy controls (n = 8, mean age = 40.4 ± 4.2 yr) were studied without GH. The GH replacement during exercise on the +GH study mimicked the endogenous GH profile seen in healthy controls. No significant difference in resting free fatty acid (FFA) flux was found between study days, but during exercise a greater FFA flux was found when GH was administered (211 ± 26 vs. 168 ± 28 μmol/min, P < 0.05) and remained elevated throughout recovery (P < 0.05). With GH administered, the exercise FFA flux was not significantly different from that observed in control subjects (188 ± 14 μmol/min), but the recovery flux was greater on the +GH day than in the controls (169 ± 17 vs. 119 ± 11 μmol/min, respectively, P < 0.01). A significant time effect (P < 0.01) for glucose rate of appearance from rest to exercise and recovery occurred in the GH-deficient adults and the controls, whereas there were no differences in glucose rate of disappearance. No significant effect across time was found for protein muscle balance. In conclusion, 1) acute exposure to GH during exercise stimulates the FFA release and turnover in GH-deficient adults, 2) GH does not significantly impact glucose or protein metabolism during exercise, and 3) the exercise-induced secretion of GH plays a significant role in the regulation of fatty acid metabolism.

Original languageEnglish (US)
Pages (from-to)747-753
Number of pages7
JournalJournal of Applied Physiology
Volume96
Issue number2
DOIs
StatePublished - Feb 2004

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Nonesterified Fatty Acids
Growth Hormone
Exercise
Glucose
Muscle Proteins
Palmitates

Keywords

  • Glucose turnover
  • Growth hormone
  • Lipolysis
  • Protein turnover

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Acute exposure to GH during exercise stimulates the turnover of free fatty acids in GH-deficient men. / Kanaley, Jill A.; Dall, Rolf; Møller, Niels; Nielsen, Sven C.; Christiansen, Jens Sandahl; Jensen, Michael Dennis; Jørgensen, Jens Otto Lunde.

In: Journal of Applied Physiology, Vol. 96, No. 2, 02.2004, p. 747-753.

Research output: Contribution to journalArticle

Kanaley, Jill A. ; Dall, Rolf ; Møller, Niels ; Nielsen, Sven C. ; Christiansen, Jens Sandahl ; Jensen, Michael Dennis ; Jørgensen, Jens Otto Lunde. / Acute exposure to GH during exercise stimulates the turnover of free fatty acids in GH-deficient men. In: Journal of Applied Physiology. 2004 ; Vol. 96, No. 2. pp. 747-753.
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